SynthesisThe journal of headache and pain2024
Reconceptualizing autonomic function testing in migraine: a systematic review and meta-analysis.
Synthesis in The journal of headache and pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Migraine and the risk of glaucoma: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Clinical Outcomes of Ultrasound-Guided Stellate Ganglion Block in Highly Treatment-Resistant Chronic Migraine: A 6-Month Prospective Single-Group Interventional Study.Medicina (Kaunas, Lithuania) · 2026Article
- Evaluation of Atrial and Ventricular Myocardial Repolarization Markers During Acute Migraine Attack.Journal of clinical medicine · 2026Article
- A Holistic and Dynamic Network-Level View of the Autonomic Nervous System.Annual review of biomedical engineering · 2026Review
- Article
- Investigating the relationship between vasovagal syncope and migraine: a case-control study among Lebanese patients.Journal of oral & facial pain and headache · 2025Article
- Cognitive and autonomic dysfunction in individuals with migraine: are they modifiable?Arquivos de neuro-psiquiatria · 2025Article
- Mechanisms and clinical applications of the valsalva maneuver in migraine relief: A mini-review.Current journal of neurology · 2025Article
- Novel Conservative Therapies in Migraine Management: The Impact of Fascia Exercises in a Randomized Controlled Trial.Journal of clinical medicine · 2025Article
- Influence of next-generation artificial intelligence on headache research, diagnosis and treatment: the junior editorial board members' vision - part 2.The journal of headache and pain · 2025Review
- Relationship Between Frequency Domain Indicators of Heart Rate Variability and Both Age and Duration of Illness in Patients with Headache: A Cross-Sectional Study.Biomedicines · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutonomic nervous system (ANS) testing has aided in our ability to evaluate autonomic dysfunction in migraine patients. We reviewed the literature in multiple databases which investigate ANS function in migraine patients and healthy subjects.
methodsThis systematic review and meta-analysis examined the respective deep breathing, Valsalva manoeuvre, orthostatic and isometric challenge results, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analyses of Observational Studies in Epidemiology (MOOSE) statements.
resultsSeven articles met all inclusion criteria. Fixed-effects meta-analysis showed migraine patients (n = 424), collectively, had lower interictal autonomic test results compared with healthy controls (n = 268). In detail, this was true for the standardized mean difference (g) of deep breathing (g= -0.32; 95% confidence interval (CI) -0.48, -0.16), orthostatic challenge (g= -0.28; 95% CI -0.44, -0.13) and isometric challenge (g= -0.55; 95% CI -0.71, -0.39) and for the difference of means (MD) of the Valsalva ratio (MD = -0.17; 95% CI -0.23, -0.10).
conclusionsInterictal ANS dysfunction can be identified in migraine patients when compared to healthy controls. These findings indicate the importance to evaluate ANS function in migraine patients - especially, as migraine-specific prophylactic therapies (such as anti-calcitonin gene-related peptide (CGRP) antibodies) may affect the function of the ANS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.