Evidence map›Paper›PMID 38600440›Full record

ArticleBMC cancer2024

Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma.

E Routila, R Mahran, S Salminen, H Irjala, E Haapio, E Kytö, S Ventelä, K Petterson, J Routila, K Gidwani and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

E RoutilaDepartment of Life Technologies, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland. erica.routila@utu.fi.
R MahranDepartment of Life Technologies, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
S SalminenDepartment of Life Technologies, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
H IrjalaDepartment for Otorhinolaryngology- Head and Neck surgery, University of Turku and Turku University Hospital, Savitehtaankatu 5, 20520, Turku, Finland.
E HaapioDepartment for Otorhinolaryngology- Head and Neck surgery, University of Turku and Turku University Hospital, Savitehtaankatu 5, 20520, Turku, Finland.
E KytöDepartment for Otorhinolaryngology- Head and Neck surgery, University of Turku and Turku University Hospital, Savitehtaankatu 5, 20520, Turku, Finland.
S VenteläFICAN West Cancer Centre, Turku, Finland.
K PettersonDepartment of Life Technologies, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
J RoutilaFICAN West Cancer Centre, Turku, Finland.
K GidwaniDepartment of Life Technologies, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
J LeivoDepartment of Life Technologies, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
University of Turku · FITurku University Hospital · FIÅbo Akademi University · FI

Funding

Research Council of Finland's Flagship InFLAMES 337530
6 · The paper itself

Abstract

backgroundAltered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors.

methodsTumor, adjacent normal tissue, and blood samples of 25 patients were collected together with clinical details. After tissue processing, lectin-based glycovariant screens were performed.

resultsStrong correlation between glycosylation profiles of all four stemness-related proteins was observed in tumor tissue, whereas glycosylation in tumor tissue, adjacent normal tissue, and serum was differential.

conclusionsA mannose- and galactose-rich glycosylation niche associated with stemness-related proteins was identified.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsCell Line, TumorCytoskeletal ProteinsGlycosylationHumansSquamous Cell Carcinoma of Head and NeckCytoskeletal ProteinsLIMA1 protein, humanBioaffinity assayGlycosylationHNSCCLectinStemness

Identifiers

PMID38600440
PMCPMC11005150
OpenAlexW4394689984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.