Evidence map›Paper›PMID 38600414›Full record

ArticleOral and maxillofacial surgery2024

Relationship between tumor thickness and GATA3 immunoexpression in lip and tongue squamous cell carcinomas.

Arthur Geovanni Borges Vital, Maria Carolina Magalhães de Carvalho, Caio Rodrigues Maia, Hébel Cavalcanti Galvão, Lélia Batista de Souza, Pedro Paulo de Andrade Santos

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Article in Oral and maxillofacial surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Arthur Geovanni Borges VitalDentistry Undergraduate, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Maria Carolina Magalhães de CarvalhoDentistry Undergraduate, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Caio Rodrigues MaiaPostgraduate Program in Dental Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Hébel Cavalcanti GalvãoDepartment of Pathology, Health Sciences Center at Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Lélia Batista de SouzaDepartment of Pathology, Health Sciences Center at Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Pedro Paulo de Andrade SantosDepartment of Morphology, Biosciences Center, Federal University of Rio Grande do Norte (UFRN), Campus Universitário Lagoa Nova, Centro de Biociências, Natal, RN, Brazil. ppdasantos@gmail.com.

Funding

National Council for Scientific and Technological Development (CNPq) Universal CNPq nº 424589/2016-8
6 · The paper itself

Abstract

purposeLower lip squamous cell carcinomas (LLSCCs) exhibit lower levels of aggressiveness, low relations with metastases and better prognosis when compared with intraoral squamous cell carcinomas. Differently from the oral tongue squamous cell carcinomas (OTSCCs) have a high tendency towards local invasion and lymph nodal dissemination. Our aim was to evaluate tumor thickness in cases of oral squamous cell carcinoma and correlate it with histological grade of malignancy and GATA3 immunoreactivity.

methodsSixty specimens (30 LLSCCs and 30 OTSCCs) were scanned and digitized for the subsequent measurement of tumor thickness, histopathological examination, and quantitative analysis of GATA3 in the parenchyma and stroma of the tumors.

resultsTumor thickness was lower in LLSCC compared to OTSCCs. Immunohistochemical analysis of GATA3 in parenchyma, stroma and both compartments showed higher immunoreactivity in LLSCCs compared to OTSCCs. We observed a negative correlation between tumor thickness and GATA3 expression in parenchyma, stroma, and both compartments. Our results revealed the presence of GATA3 in all cases both in the parenchyma and in the stroma. Higher expression was more related to LLSCCs, which are known to be less aggressive tumors than OTSCCs.

conclusionsA greater tumor thickness was found in OTSCCs, which was correlated with lower expression of GATA3, suggesting that this protein is involved in the inhibition of proliferative, migratory, and invasive capacity.

Indexed as

Carcinoma, Squamous CellGATA3 Transcription FactorLip NeoplasmsTongue NeoplasmsAdultAgedAged, 80 and overFemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessGATA3 protein, humanGATA3 Transcription FactorGATA3 transcription factorImmunohistochemistryLip neoplasmsNeoplasm invasionTongue neoplasms

Identifiers

PMID38600414

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