ArticleNature2024
Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 45 citations in OpenAlex.
- Origins and timing of somatic variants in the brain.Current opinion in genetics & development · 2026Review
- Computational approaches for multimodal lineage tracing.Nature reviews. Genetics · 2026Review
- Somatic mosaicism in the brain: linking development, ageing and neurodegeneration.Nature reviews. Neurology · 2026Review
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- ARX mutation-associated interneuron defects provide insights into mechanisms underlying developmental epilepsies.Brain : a journal of neurology · 2026Article
- Oligodendroglial somatic SNCA copy number gains are associated with inclusions and disease onset in multiple system atrophy.Acta neuropathologica · 2026Article
- Article
- Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex.Communications biology · 2026Article
- Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway.Research square · 2026Article
- Disease insights from brain somatic mosaicism.Experimental & molecular medicine · 2026Review
- Article
- Integrated ERK-PKA-YAP/TAZ-SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.Cell reports · 2025Article
- Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Nature reviews. Genetics · 2025Review
- Article
- Functional phenotyping of genomic variants using joint multiomic single-cell DNA-RNA sequencing.Nature methods · 2025Article
- Accelerated Tempo of Cortical Neurogenesis in Down Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate.bioRxiv : the preprint server for biology · 2025Article
- Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues.bioRxiv : the preprint server for biology · 2025Article
- Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Changuk Chung *Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Xiaoxu Yang *Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-0219-0023
Robert F HevnerSanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
Katie KennedyBioSkryb Genomics Inc., Durham, NC, USA.
Keng Ioi VongDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-5377-9845
Yang LiuDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Arzoo PatelDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Rahul NedunuriDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Scott T BartonDivision of Medical Education, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Geoffroy NoelDivision of Anatomy, School of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-2192-7756
Chelsea BarrowsDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0007-8106-9446
Valentina StanleyDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Swapnil MittalDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Martin W BreussDepartment of Pediatrics, Section of Genetics and Metabolism, University of Colorado School of Medicine, Aurora, CO, USA.
Johannes C M SchlachetzkiDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-7801-9743
Stephen F KingsmoreRady Children's Institute for Genomic Medicine, San Diego, CA, USA.
Joseph G GleesonDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA. jogleeson@health.ucsd.edu.ORCID 0000-0002-0889-9220
Children’s Institute · USUniversity of California San Diego · USUniversity of Colorado Denver · US
Funding
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Subhojit Roy · 2019 to 2026
$34.9MMosaicism in focal cortical dysplasias spectrum seen in neuropsychiatric diseaseU01MH108898 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2015 to 2019
$5.1MOrigins of Brain Somatic Mosaicism in Developmental Brain DiseaseR01MH124890 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2021 to 2025
$1.5MIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kUnderstanding genomic stability between generations by assessing mutational burdens in single spermsR00HD111686 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Xiaoxu Yang · 2025 to 2026
$498kMechanisms controlling HIV latency and pathogenesis in microgliaR21MH134401 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHLACHETZKI, JOHANNES CAROLUS MAGNUS, YANG, XIAOXU · 2023 to 2023
$435kUnderstanding genomic stability betweengenerations by assessing mutational burdens in single spermsK99HD111686 · NICHD · UNIVERSITY OF UTAH · PI YANG, XIAOXU · 2023 to 2024
$232kNIA NIH HHS P30 AG062429NICHD NIH HHS K99 HD111686NICHD NIH HHS R00 HD111686NIH HHS S10 OD026929NIMH NIH HHS R01 MH124890NIMH NIH HHS R21 MH134401NIMH NIH HHS U01 MH108898
Abstract
Debate remains around the anatomical origins of specific brain cell subtypes and lineage relationships within the human forebrain
Indexed as
Cell LineageClone CellsMosaicismNeuronsProsencephalonAgedAllelesFemaleGABAergic NeuronsHippocampusHomeodomain ProteinsHumansNeocortexNeural InhibitionParietal LobeSingle-Cell AnalysisDistal-less homeobox proteinsHomeodomain ProteinsTranscription Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.