ArticleNature2024
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Pooled it
- Automated kinetic-scheme-free sorting of single-molecule fluorescence events using a deep learning based hidden-state method.Nature communications · 2026Article
- TRiC-assisted folding of class I HDAC family proteins regulated by distinct co-chaperone and cofactor networks.Science advances · 2026Article
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- Emission dipole orientation reveals dynamic single-molecule interactions with 2D crystals at solvent interfaces.Nature communications · 2026Article
- Emerging Insights into the Distinct Pharmacological Mechanisms of Buprenorphine.Journal of chemical information and modeling · 2026Article
- Activation dynamics of a water-soluble human mu-opioid receptor.The Journal of biological chemistry · 2026Article
- Determinants of drug efficacy and the dynamics of G protein activation.Nature structural & molecular biology · 2026Article
- Ligand Binding Dynamics of Ion Channels and GPCRs Using Single-Molecule Fluorescence.Annual review of biophysics · 2026Review
- Identification of Subtype-Selective Binding Sites in the Opioid Receptor Family.Journal of chemical information and modeling · 2026Article
- Article
- Unraveling allosteric signaling of G protein-coupled receptors (GPCRs) by single-molecule fluorescence.Biophysical reviews · 2026Review
- Membrane cholesterol modulates engagement of β-arrestin with the ghrelin receptor.Communications biology · 2026Article
- Mechanistic insights into the therapeutic properties of delta opioid receptor.Science advances · 2026Article
- Protocol for preparing and characterizing samples for combined microsecond freeze-hyperquenching and electron paramagnetic resonance spectroscopy.STAR protocols · 2026Article
- Swapped and non-swapped TRAAK states co-exist in membranes at a ratio influenced by temperature.Nature communications · 2026Article
- Psychedelics elicit their effects by 5-HTNature · 2026Article
- Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators.bioRxiv : the preprint server for biology · 2026Article
- Article
- The Role of Intrinsically Disordered Domains in Regulating G Protein-Coupled Receptor Signaling.Journal of the American Chemical Society · 2026Article
Corrections and comments
- Update of
Authors and funding
12 authors at 6 institutions in 4 countries.
Jiawei Zhao *State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.ORCID 0000-0002-0582-2105
Matthias Elgeti *Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. matthias.elgeti@uni-leipzig.de.ORCID 0000-0002-0550-4852
Evan S O'BrienDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Cecília P SárInstitute of Organic and Medicinal Chemistry, School of Pharmaceutical Sciences, University of Pécs, Pécs, Hungary.
Amal Ei DaibaniDepartment of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.
Jie HengState Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.
Xiaoou SunState Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.
Elizabeth WhiteDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Tao CheDepartment of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-1620-3027
Wayne L HubbellJules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.ORCID 0000-0001-5958-3990
Chunlai ChenState Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China. chunlai@mail.tsinghua.edu.cn.ORCID 0000-0002-0128-7766
Center for Life Sciences · CNStanford University · USUniversity of California, Los Angeles · USWashington University in St. Louis · USTsinghua University · CNUniversity of Pecs · HU
Funding
Structural Basis of Opioid Receptor FunctionR37DA036246 · NIDA · STANFORD UNIVERSITY · PI KOBILKA, BRIAN K · 2013 to 2020
$4.2MThe structural basis for pathway-selective signaling by the µ opioid receptorR01DA036246 · NIDA · STANFORD UNIVERSITY · PI Brian K Kobilka · 2024 to 2026
$1.6MExploring the Conformational Landscape of G Protein Coupled ReceptorsR01GM137081 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELGETI, AXEL PETER MATTHIAS · 2021 to 2022
$640kNIDA NIH HHS R01 DA036246NIDA NIH HHS R37 DA036246NIGMS NIH HHS R01 GM137081
Abstract
The µ-opioid receptor (µOR) is an important target for pain management
Indexed as
LigandsProtein ConformationReceptors, Opioid, mubeta-Arrestin 1Binding SitesFluorescence Resonance Energy TransferGTP-Binding Protein alpha Subunits, Gi-GoGuanosine DiphosphateHumansModels, MolecularProtein BindingSingle Molecule Imagingbeta-Arrestin 1GTP-Binding Protein alpha Subunits, Gi-GoGuanosine DiphosphateLigandsReceptors, Opioid, mu
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.