ArticleNature2024
Necroptosis blockade prevents lung injury in severe influenza.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
21.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Programmed cell death in human respiratory syncytial virus infection.Frontiers in cellular and infection microbiology · 2025Pooled it
- MNS induces antiviral protection and suppresses inflammation.Annals of medicine · 2026Article
- Mechanisms, regulation and clinical relevance of necroptosis.Nature reviews. Molecular cell biology · 2026Review
- A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease-Like Autoinflammatory Syndrome.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- HIGH DOSE GAMMAHERPESVIRUS INFECTION IN MACROPHAGES RESULTS IN INFLAMMATORY MULTIMODAL CELL DEATH.bioRxiv : the preprint server for biology · 2026Article
- The Acute Respiratory Distress Syndrome (ARDS): epidemiology, etiology, molecular mechanisms, diagnosis and therapeutic strategies.Molecular biomedicine · 2026Review
- The kinase domain of RIPK3 tunes its scaffolding functions.Cell death and differentiation · 2026Article
- Single-cell RNA sequencing of hematopoietic and non-hematopoietic cells defines a distinct signature in atopic and NRG1 mouse lung.Scientific reports · 2026Article
- Complementary Protective Effects of Lactiplantibacillus Plantarum GUANKE and Picolinic Acid Against Influenza A Virus Infection in Mice.Probiotics and antimicrobial proteins · 2026Article
- Long noncoding RNA#61 synergizes with viral PA-X to augment pyroptosis and attenuate the virulence of highly pathogenic H5N1 influenza virus in mice.Journal of virology · 2026Article
- Cathepsin C Restricts Influenza A Virus Replication and Is Associated with Suppression of the PI3K-AKT Signaling Pathway.Viruses · 2026Article
- Degradation of ACSL3 by influenza A virus shifts unfolded protein response from antiviral defense to viral evasion.Virologica Sinica · 2026Article
- Integrative bioinformatics and machine learning reveal an association of LTF and MMP8 with systemic inflammation and lung injury.Respiratory research · 2026Article
- Transcriptomics and network pharmacology reveal that baicalin alleviates acute lung injury induced by H1N1 via targeting STAT1.Archives of microbiology · 2026Article
- Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging.Nature communications · 2026Article
- Identification of Mannose-Capped-Arabinomannan 101-mer as a Potential Influenza Virus Vaccine Adjuvant.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bilirubin directly activates RIPK3 to induce non-classical necroptosis.Cell discovery · 2026Article
- Status and outlook of mRNA therapeutics for viral diseases.EMBO molecular medicine · 2026Review
- A viable kinase-inactive RIPK3 D143N mouse model reveals its scaffold function in driving TNF-induced inflammatory disorder.Cell death discovery · 2026Article
- Dissecting Cell Death Pathways in Influenza A Virus Infection: Comparative Insights from Human Models.Viruses · 2026Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
34 authors at 6 institutions in 2 countries.
Avishekh Gautam *Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
David F Boyd *Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Sameer NikharDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA.ORCID 0000-0002-0542-4545
Ting ZhangCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Ioannis SiokasDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
Lee-Ann Van de VeldeDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0009-0000-6205-1151
Jessica GaevertDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-4043-2161
Victoria MeliopoulosDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-1442-9177
Bikash ThapaCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Diego A RodriguezDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-4771-0221
Kathy Q CaiCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Chaoran YinCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Daniel SchnepfInstitute of Virology Department for Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-7528-981X
Julius BeerInstitute of Virology Department for Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Carly DeAntoneoCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Riley M WilliamsCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Maria ShubinaCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Brandi LivingstonDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.
Dingqiang ZhangDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
Mark D AndrakeCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0003-2957-4350
Seungheon LeeDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA.ORCID 0000-0002-5150-4327
Raghavender BodaDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA.
Anantha L DuddupudiDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA.
Jeremy Chase CrawfordDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-4096-6048
Peter VogelDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-7535-0545
Christian LochReaction Biology, Malvern, PA, USA.
Martin SchwemmleInstitute of Virology Department for Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-2972-6855
Lawrence C FritzVaayu Therapeutics, Rancho Santa Fe, CA, USA.
Stacey Schultz-CherryDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2021-727X
Douglas R GreenDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-7332-1417
Gregory D CunyDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA. gdcuny@central.uh.edu.ORCID 0000-0002-3188-4748
Paul G ThomasDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA. paul.thomas@stjude.org.ORCID 0000-0001-7955-0256
Alexei DegterevDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA. alexei.degterev@tufts.edu.ORCID 0000-0002-8240-7132
Siddharth BalachandranCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA. Siddharth.balachandran@fccc.edu.ORCID 0000-0003-2084-1803
St. Jude Children's Research Hospital · USFox Chase Cancer Center · USUniversity of Houston · USTufts University · USUniversity of Freiburg · DEReaction Biology Corporation (United States) · US
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8MNIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4MCOVID Supplement - COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES,75N93019C00052 · NIAID · UNIVERSITY OF GEORGIA · PI ROSS, TED · 2019 to 2025
$74.6MNIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00018 · NIAID · UNIVERSITY OF GEORGIA · PI TOMPKINS, S. MARK · 2021 to 2025
$21.6MMECHANISMS OF REGULATED CELL DEATHR35CA231620 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2018 to 2026
$9.2MMechanism, Function, and Exploitation of Influenza A Virus-Activated Cell DeathR01AI135025 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH · 2017 to 2025
$6.8MSurvival Function of the Fadd-Caspase-8-Flip Complex - MERIT ExtensionR37AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2017 to 2026
$4.5MTargeting RIPK3 in Flu-Associated Lung InjuryR01AI144400 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH, CUNY, GREGORY D · 2019 to 2023
$3.6MRole of ZBP1 in pathogenesis of Salmonella biofilmsR01AI171568 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI SIDDHARTH BALACHANDRAN, Cagla Tukel · 2023 to 2026
$3.4MSmall-molecule exploitation of ZBP1-driven nuclear necroptosis for cancer immunotherapyR01CA269975 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI SIDDHARTH BALACHANDRAN, VASILY M STUDITSKY · 2023 to 2026
$3.0MUnderstanding and targeting fibroblast activation in influenza-triggered lung inflammation and post-viral diseaseR01HL170121 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI David Fielding Boyd · 2023 to 2026
$2.5MHarnessing ZBP1-triggered cell death to enhance influenza vaccine responsivenessR56AI168087 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH, LANGLOIS, RYAN · 2023 to 2023
$834kNCI NIH HHS P30 CA006927NCI NIH HHS R01 CA269975NCI NIH HHS R35 CA231620NHLBI NIH HHS R01 HL170121NIAID NIH HHS 75N93019C00052NIAID NIH HHS 75N93021C00016NIAID NIH HHS 75N93021C00018NIAID NIH HHS R01 AI135025NIAID NIH HHS R01 AI144400NIAID NIH HHS R01 AI171568NIAID NIH HHS R21 AI144828NIAID NIH HHS R21 AI164003NIAID NIH HHS R21 AI168799NIAID NIH HHS R37 AI044828NIAID NIH HHS R56 AI168087NIH HHS S10 OD030332
Abstract
Severe influenza A virus (IAV) infections can result in hyper-inflammation, lung injury and acute respiratory distress syndrome
Indexed as
Lung InjuryNecroptosisOrthomyxoviridae InfectionsProtein Kinase InhibitorsReceptor-Interacting Protein Serine-Threonine KinasesAlveolar Epithelial CellsAnimalsFemaleHumansInfluenza A virusMaleMiceMice, Inbred C57BLRespiratory Distress SyndromeProtein Kinase InhibitorsReceptor-Interacting Protein Serine-Threonine KinasesRIPK3 protein, humanRipk3 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.