ArticleNature2024
Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 2 pooled it
65.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
133 citing papers in PubMed, 2 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- Corticosteroid Usage in Modeling Gulf War Illness in Pre-Clinical Models: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Global clinical trials on stem cell therapy for autoimmune diseases: trends and future directions.Frontiers in immunology · 2025Pooled it
- Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial.Nature medicine · 2026Trial
- Ternary mTOR-targeted conductive nanofibrous scaffolds with bioactive peptides orchestrate immune-metabolic-fibrotic balance for diabetic bone regeneration.Bioactive materials · 2026Article
- Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways.Bioscience reports · 2026Review
- Model Systems infrastructure of the German Center for Mental Health (DZPG): toward an integrated, mechanism-based framework for mental health research.European archives of psychiatry and clinical neuroscience · 2026Review
- Biomimetic M2 exosome-based dual-drug nanoplatform for combined immunomodulation and bone protection in rheumatoid arthritis.Bioactive materials · 2026Article
- Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026Review
- Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026Review
- Macrophage immunometabolic reprogramming in inflammatory repair failure in osteonecrosis of the femoral head.Journal of orthopaedic translation · 2026Review
- Macrophage programming in systemic sclerosis: Niches, networks, and translational horizons.Seminars in immunopathology · 2026Review
- Article
- Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi-Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Mitochondrial transfer via ADSC-EVs reprograms glucose/glutamine metabolism to restore TCA cycle-driven M2 polarization in diabetic wounds.Journal of nanobiotechnology · 2026Article
- CD163Biomarker research · 2026Article
- Review
- Oligodendrocyte Egr2 Mediates the Beneficial Effect of Resocialization on the Social Ability of Socially Isolated Mice.Neuroscience bulletin · 2026Article
- Glucocorticoids induce a phagocytic C1Q+ macrophage phenotype primed for IFNγ-dependent CXCL9 secretion.Scientific reports · 2026Article
- Biomimetic hybrid nanoparticles for dual regulation of macrophage pyroptosis and metabolism in rheumatoid arthritis.Journal of nanobiotechnology · 2026Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 10 institutions in 3 countries.
Jean-Philippe AugerDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Max ZimmermannDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Maria FaasDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Ulrich StifelInstitute of Comparative Molecular Endocrinology (CME), Ulm University, Ulm, Germany.ORCID 0000-0001-8535-8156
David ChambersDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0003-3716-3172
Brenda KrishnacoumarLeibniz-Institut für Analytische Wissenschaften, ISAS, e.V, Dortmund, Germany.
R Verena TaudteInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0003-4617-6063
Charlotte GrundDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Gitta ErdmannDivision of the Molecular Biology of the Cell I, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Carina ScholtysekDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Stefan UderhardtDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Oumaima Ben BrahimDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Mónica Pascual MatéDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Cornelia StollDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Martin BöttcherDeutsches Zentrum für Immuntherapie (DZI), University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0003-2911-8830
Katrin Palumbo-ZerrDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Matthew S J ManganInstitute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.
Maria DzamukovaDepartment of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Markus KielerInstitute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.ORCID 0000-0002-4082-5731
Melanie HofmannInstitute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.ORCID 0000-0002-0835-4183
Stephan BlümlDivision of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-2758-4400
Gernot SchabbauerInstitute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.ORCID 0000-0002-7490-8009
Dimitrios MougiakakosDeutsches Zentrum für Immuntherapie (DZI), University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0002-2817-6660
Uwe SonnewaldDivision of Biochemistry, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Germany.
Fabian HartmannDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0001-6106-1657
David SimonDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0001-8310-7820
Arnd KleyerDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0002-2026-7728
Anika GrüneboomLeibniz-Institut für Analytische Wissenschaften, ISAS, e.V, Dortmund, Germany.ORCID 0000-0002-7928-5613
Susetta FinottoDepartment of Molecular Pneumology, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Eicke LatzInstitute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.
Jörg HofmannDivision of Biochemistry, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0001-7387-1569
Georg SchettDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0001-8740-9615
Jan TuckermannInstitute of Comparative Molecular Endocrinology (CME), Ulm University, Ulm, Germany.ORCID 0000-0003-3691-275X
Gerhard KrönkeDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany. gerhard.kroenke@charite.de.ORCID 0000-0002-7566-4325
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEChristian Doppler Laboratory for Thermoelectricity · ATLeibniz Institute for Analytical Sciences - ISAS · DEUniversität Ulm · DEUniversity of Bonn · DECharité - Universitätsmedizin Berlin · DEGerman Cancer Research Center · DEMedical University of Vienna · ATPhilipps University of Marburg · DEUniversitätsklinikum Erlangen · DE
Funding
Canadian Institutes for Health ResearchDeutsche ForschungsgemeinschaftMajor Research Instrumentation
Abstract
Glucocorticoids represent the mainstay of therapy for a broad spectrum of immune-mediated inflammatory diseases. However, the molecular mechanisms underlying their anti-inflammatory mode of action have remained incompletely understood
Indexed as
Anti-Inflammatory AgentsGlucocorticoidsInflammationMacrophagesMitochondriaSuccinatesAnimalsCarboxy-LyasesCitric Acid CycleCytokinesEnzyme ActivationFemaleHumansHydro-LyasesMaleMiceAcod1 protein, mouseaconitate decarboxylaseAnti-Inflammatory AgentsCarboxy-LyasesCytokinesGlucocorticoidsHydro-Lyasesitaconic acidPyruvate Dehydrogenase ComplexReceptors, GlucocorticoidSuccinates
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.