ArticleNature communications2024
A membrane associated tandem kinase from wild emmer wheat confers broad-spectrum resistance to powdery mildew.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
- Gb3 encodes a unique kinase fusion protein conferring greenbug resistance in wheat.Nature genetics · 2026Article
- A transmembrane protein confers the Yr26/Yr24/YrCH42/YrG22-mediated stripe rust resistance in wheat.Nature communications · 2026Article
- Resistance to the oat leaf blotch pathogen (Pyrenophora avenae) is delimited to a region of chromosome 1D that harbors a candidate resistance kinase fusion protein.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Dynamics of H3K4me3 and H3K36me3 histone modifications in response to powdery mildew infection in common wheat.BMC plant biology · 2026Article
- Comparative Proteomic Analysis Reveals That TaCAD-A1 Enhances Resistance of Wheat to Powdery Mildew (Life (Basel, Switzerland) · 2026Article
- Fine mapping of the TdHLS gene controlling hairy leaf sheath from wild emmer wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The emerging role of kinase fusion proteins in cereal immunity.Nature genetics · 2026Review
- Fine mapping of a powdery mildew resistance gene PmCWI16926 from cultivated emmer wheat.Communications biology · 2026Article
- Fine mapping and candidate gene dissection of the wheat powdery mildew resistance gene PmPBDH.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Dissecting the population structure, diversity and genetic architecture of rust resistance in wild emmer wheat (Triticum turgidum subsp. dicoccoides).BMC genomics · 2026Article
- Pm37 as a susceptible Sr22 allele confers resistance to wheat powdery mildew and leaf rust.Nature communications · 2026Article
- Two complementary NLRs from wild emmer wheat confer powdery mildew resistance.Nature communications · 2025Article
- An NLR pair in the Pm68 locus confers powdery mildew resistance in durum and common wheat.Nature communications · 2025Article
- Paired NLRs originated from Triticum dicoccoides coordinately confer resistance to powdery mildew in wheat.Nature communications · 2025Article
- Identification and characterization of a novel powdery mildew resistance gene PmCWI45575 in wild emmer wheat.BMC plant biology · 2025Article
- Genetic Basis Identification of aPlants (Basel, Switzerland) · 2025Article
- Fine mapping of a powdery mildew resistance gene PmLF540 from wild emmer wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Fine-mapping of sm6.1, a novel locus conferring resistance to gray leaf spot from Solanum habrochaites accession LA1777.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- k-mer-based GWAS in a wheat collection reveals novel and diverse sources of powdery mildew resistance.Genome biology · 2025Article
- Fine mapping of a novel powdery mildew resistance gene PmDM8 derived from a cultivated emmer (Triticum dicoccum).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
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Authors and funding
29 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crop wild relatives offer natural variations of disease resistance for crop improvement. Here, we report the isolation of broad-spectrum powdery mildew resistance gene Pm36, originated from wild emmer wheat, that encodes a tandem kinase with a transmembrane domain (WTK7-TM) through the combination of map-based cloning, PacBio SMRT long-read genome sequencing, mutagenesis, and transformation. Mutagenesis assay reveals that the two kinase domains and the transmembrane domain of WTK7-TM are critical for the powdery mildew resistance function. Consistently, in vitro phosphorylation assay shows that two kinase domains are indispensable for the kinase activity of WTK7-TM. Haplotype analysis uncovers that Pm36 is an orphan gene only present in a few wild emmer wheat, indicating its single ancient origin and potential contribution to the current wheat gene pool. Overall, our findings not only provide a powdery mildew resistance gene with great potential in wheat breeding but also sheds light into the mechanism underlying broad-spectrum resistance.
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