Evidence map›Paper›PMID 38600104›Full record

ArticleNature communications2024

The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus.

Annefleur C Langedijk, Bram Vrancken, Robert Jan Lebbink, Deidre Wilkins, Elizabeth J Kelly, Eugenio Baraldi, Abiel Homero Mascareñas de Los Santos, Daria M Danilenko, Eun Hwa Choi, María Angélica Palomino and 22 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 19 countries.

Annefleur C Langedijk *Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA, Utrecht, the Netherlands.
Bram Vrancken *Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Herestraat 49, 3000, Leuven, Belgium.ORCID http://orcid.org/0000-0001-6547-5283
Robert Jan LebbinkDepartment of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-1981-0420
Deidre WilkinsTranslational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, 1 MedImmune Way, Gaithersburg, MD, USA.
Elizabeth J KellyTranslational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, 1 MedImmune Way, Gaithersburg, MD, USA.ORCID http://orcid.org/0000-0002-6988-8576
Eugenio BaraldiDepartment of Woman's and Child's Health, University Hospital of Padova, Padova, Italy.
Abiel Homero Mascareñas de Los SantosJose Eluterio Gonzalez Hospital Universitario, Monterrey, Mexico.
Daria M DanilenkoSmorodintsev Research Institute of Influenza, St. Petersburg, Russia.ORCID http://orcid.org/0000-0001-6174-0836
Eun Hwa ChoiSeoul National University Children's Hospital, Seoul, South Korea.
María Angélica PalominoHospital Roberto del Río, Universidad de Chile, Santiago, Chile.
Hsin ChiMacKay Children's Hospital, New Taipei, Taiwan, ROC.ORCID http://orcid.org/0000-0002-2385-344X
Christian KellerInstitute of Virology, University Hospital Giessen and Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0075-7199
Robert CohenUniversité Paris XII, Créteil, France.
Jesse PapenburgMcGill University Health Centre, Montreal, QC, Canada.
Jeffrey PernicaMcMaster University, Hamilton, ON, Canada.
Anne GreenoughReSViNET Foundation, Zeist, the Netherlands.ORCID http://orcid.org/0000-0002-8672-5349
Peter RichmondUniversity of Western Australia, Perth, WA, Australia.
Federico Martinón-TorresReSViNET Foundation, Zeist, the Netherlands.ORCID http://orcid.org/0000-0002-9023-581X
Terho HeikkinenReSViNET Foundation, Zeist, the Netherlands.
Renato T SteinReSViNET Foundation, Zeist, the Netherlands.
Mitsuaki HosoyaFukushima Medical University School of Medicine, Fukushima, Japan.
Marta C NunesReSViNET Foundation, Zeist, the Netherlands.ORCID http://orcid.org/0000-0003-3788-878X
Charl VerweyDepartment of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Anouk EversDepartment of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.
Leyla Kragten-TabatabaieReSViNET Foundation, Zeist, the Netherlands.
Marc A SuchardDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0001-9818-479X
Sergei L Kosakovsky PondInstitute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, 801 N Broad St, Philadelphia, PA, 19122, USA.
Chiara PolettoINSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique IPLESP, F75012, Paris, France.ORCID http://orcid.org/0000-0002-4051-1716
Vittoria ColizzaINSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique IPLESP, F75012, Paris, France.ORCID http://orcid.org/0000-0002-2113-2374
Philippe LemeyDepartment of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Herestraat 49, 3000, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2826-5353
Louis J BontDepartment of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA, Utrecht, the Netherlands. l.bont@umcutrecht.nl.ORCID http://orcid.org/0000-0003-3099-4475
INFORM-RSV Study Group
AstraZeneca (United States) · USComplejo Hospitalario Universitario de Santiago · ESFukushima Medical University · JPHeidelberg University · DEHospital Roberto del Rio · CLInserm · FRKing's College London · GBPontifícia Universidade Católica do Rio Grande do Sul · BRResearch Institute of Influenza · RUSeoul National University Children's Hospital · KRThe University of Western Australia · AUUniversitätsklinikum Gießen und Marburg · DEUniversity of Padua · ITAltrecht GGZ · NLHospital Universitario Dr José Eleuterio Gonzalez · MXMackay Memorial Hospital · TWMcGill University Health Centre · CAMcMaster University · CASouth African Medical Research Council · ZATemple University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread.

Indexed as

Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsChildChild, PreschoolGenomicsHumansInfantPhylogeny

Identifiers

PMID38600104
PMCPMC11006891
OpenAlexW4394688408

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.