An Autopsy Case of Antineutrophil Cytoplasmic Antibody-associated Vasculitis Induced by Propylthiouracil.

Genki Fujii, Ryosuke Yoshihara, Toshiki Hyodo, Ikuhiro Ishida, Ryoko Onishi, Masayo Fujimoto, Keiji Iida

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Genki FujiiDivision of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Japan.

Ryosuke YoshiharaDivision of Rheumatology, Hyogo Prefectural Kakogawa Medical Center, Japan.

Toshiki HyodoDepartment of Diagnostic Pathology, Kobe University Graduate School of Medicine, Japan.

Ikuhiro IshidaDivision of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Japan.

Ryoko OnishiDivision of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Japan.

Masayo FujimotoDivision of Pathology, Hyogo Prefectural Kakogawa Medical Center, Japan.

Keiji IidaDivision of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a complication caused by antithyroid drugs, particularly propylthiouracil (PTU). Most patients experience organ failure due to the affects of the treatment regimen. We herein report the case of an 89-year-old woman whose severe AAV induced by PTU resulted in various instances of organ failure that eventually led to death after 9 years of PTU therapy. During autopsy, we identified five types of organ failure. As AAV is a potentially fatal disease, the development of various vasculitis symptoms during PTU therapy should therefore be carefully monitored.

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisAntithyroid AgentsAutopsyPropylthiouracilAged, 80 and overAntibodies, Antineutrophil CytoplasmicFatal OutcomeFemaleHumansAntibodies, Antineutrophil CytoplasmicAntithyroid AgentsPropylthiouracilantineutrophil cytoplasmic antibody (ANCA)antineutrophil cytoplasmic antibody-associated vasculitis (AAV)Autopsyorgan failurespropylthiouracil (PTU)

Identifiers

PMID38599866

DOI10.2169/internalmedicine.3397-23

PMCPMC11671207

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