Evidence map›Paper›PMID 38599855›Full record

ReviewJournal of diabetes2024

Advanced multifunctional hydrogels for diabetic foot ulcer healing: Active substances and biological functions.

Yuetong Li, Yuxin Leng, Yang Liu, Jianhua Zhong, Jiaxin Li, Shitong Zhang, Zhenlin Li, Kaming Yang, Xinyi Kong, Wanwen Lao and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yuetong LiDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yuxin LengDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Yang LiuDepartment of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Jianhua ZhongDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Jiaxin LiDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Shitong ZhangDepartment of General Practice, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Zhenlin LiDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Kaming YangDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Xinyi KongDepartment of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Wanwen LaoDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Changlong BiDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Aixia ZhaiDepartment of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.ORCID https://orcid.org/0009-0006-4488-978X
Sun Yat-sen University · CNPeking University · CN

Funding

National Natural Science Foundation of China 81871562National Natural Science Foundation of China 82072267National Natural Science Foundation of China 82172215National Natural Science Foundation of China 82272271Science and Technology Planning Project of Guangdong Province 2021A1515011396Science and Technology Planning Project of Guangdong Province 2021A1515012109Shenzhen Futian District Public Health Research Project FTWS2020008Shenzhen Futian District Public Health Research Project FTWS2020017
6 · The paper itself

Abstract

aimHydrogels with excellent biocompatibility and biodegradability can be used as the desirable dressings for the therapy of diabetic foot ulcer (DFU). This review aimed to summarize the biological functions of hydrogels, combining with the pathogenesis of DFU.

methodsThe studies in the last 10 years were searched and summarized from the online database PubMed using a combination of keywords such as hydrogel and diabetes. The biological functions of hydrogels and their healing mechanism on DFU were elaborated.

resultsIn this review, hydrogels were classified by their active substances such as drugs, cytokines, photosensitizers, and biomimetic peptide. Based on this, the biological functions of hydrogels were summarized by associating the pathogenesis of DFU, including oxidative stress, chronic inflammation, cell phenotype change, vasculopathy, and infection. This review also pointed out some of the shortcomings of hydrogels in present researches.

conclusionsHydrogels were classified into carrier hydrogels and self-functioning hydrogels in this review. Besides, the functions and components of existing hydrogels were clarified to provide assistance for future researches and clinical applications.

Indexed as

Diabetes MellitusDiabetic FootCytokinesHumansHydrogelsWound HealingCytokinesHydrogelsbiological functionsclassificationdiabetic foot ulcerhydrogelspathogenesis

Identifiers

PMID38599855
PMCPMC11006623
OpenAlexW4394684283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.