Evidence map›Paper›PMID 38599800›Full record

Trial reportBMJ paediatrics open2024

Influence of vitamin D supplementation on growth, body composition, pubertal development and spirometry in South African schoolchildren: a randomised controlled trial (ViDiKids).

Keren Middelkoop, Lisa Micklesfield, Justine Stewart, Neil Walker, David A Jolliffe, Amy E Mendham, Anna K Coussens, James Nuttall, Jonathan Tang, William D Fraser and 6 more

Registry-linked trialOpen access · diamondAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
In one paragraph

Trial report in BMJ paediatrics open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02880982 (Trial of Vitamin D Supplementation in Cape Town Primary Schoolchildren), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02880982 phase3completednot on this map

Trial of Vitamin D Supplementation in Cape Town Primary Schoolchildren

TypeinterventionalSponsorQueen Mary University of LondonRan2017 to 2022Enrolled1,743ConditionsLatent TuberculosisArmsCholecalciferol, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Effects of vitamin A and vitamin DTranslational pediatrics · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 6 countries.

Keren Middelkoop *Desmond Tutu HIV Centre, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Lisa Micklesfield *Health through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Department of Human Biology, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa.
Justine StewartDesmond Tutu HIV Centre, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Neil WalkerWolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
David A JolliffeBlizard Institiute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Amy E MendhamHealth through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Department of Human Biology, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa.
Anna K CoussensCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa.
James NuttallDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Jonathan TangNorwich Medical School, University of East Anglia, Norwich, UK.
William D FraserNorwich Medical School, University of East Anglia, Norwich, UK.
Waheedullah MomandBlizard Institiute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Cyrus CooperMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Nicholas C HarveyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Robert J WilkinsonCentre for Infectious Diseases Research in Africa, Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa.
Linda-Gail BekkerDesmond Tutu HIV Centre, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Adrian R MartineauBlizard Institiute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK a.martineau@qmul.ac.uk.ORCID http://orcid.org/0000-0001-5387-1721
Queen Mary University of London · GBDesmond Tutu HIV Foundation · ZAUniversity of Cape Town · ZASouth African Medical Research Council · ZAUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of East Anglia · GB

Funding

Medical Research Council MC_PC_21003Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/2Wellcome Trust CC2112
6 · The paper itself

Abstract

objectiveTo determine whether weekly oral vitamin D supplementation influences growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren.

designPhase 3 double-blind randomised placebo-controlled trial.

settingSocioeconomically disadvantaged peri-urban district of Cape Town, South Africa.

participants1682 children of black African ancestry attending government primary schools and aged 6-11 years at baseline.

interventionsOral vitamin D

main outcome measuresHeight-for-age and body mass index-for-age, measured in all participants; Tanner scores for pubertal development, spirometric lung volumes and body composition, measured in a subset of 450 children who additionally took part in a nested substudy.

resultsMean serum 25-hydroxyvitamin D

conclusionsWeekly oral administration of 10 000 IU vitamin D TRIAL REGISTRATION NUMBERS: ClinicalTrials.gov NCT02880982, South African National Clinical Trials Register DOH-27-0916-5527.

Indexed as

CholestanesVitamin D DeficiencyBody CompositionChildCholecalciferolDietary SupplementsDouble-Blind MethodHumansSouth AfricaSpirometryVitamin DVitaminsCholecalciferolCholestanesVitamin DVitaminsAdolescent HealthGrowth

Identifiers

PMID38599800
PMCPMC11015302
OpenAlexW4394694804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.