Evidence map›Paper›PMID 38599784›Full record

ArticleStatistics in medicine2024

A discrete approximation method for modeling interval-censored multistate data.

Lu You, Xiang Liu, Jeffrey Krischer

Abstract read
In one paragraph

Article in Statistics in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lu YouHealth Informatics Institute, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-9400-2060
Xiang LiuHealth Informatics Institute, University of South Florida, Tampa, Florida, USA.
Jeffrey KrischerHealth Informatics Institute, University of South Florida, Tampa, Florida, USA.

Funding

Dynamic prediction of type 1 diabetes risk and autoantibody status by a joint model of longitudinal and multistate modelsR03DK135437 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI YOU, LU · 2023 to 2024
$300k
NIDDK NIH HHS R03 DK135437NIDDK NIH HHS R03DK135437
6 · The paper itself

Abstract

Many longitudinal studies are designed to monitor participants for major events related to the progression of diseases. Data arising from such longitudinal studies are usually subject to interval censoring since the events are only known to occur between two monitoring visits. In this work, we propose a new method to handle interval-censored multistate data within a proportional hazards model framework where the hazard rate of events is modeled by a nonparametric function of time and the covariates affect the hazard rate proportionally. The main idea of this method is to simplify the likelihood functions of a discrete-time multistate model through an approximation and the application of data augmentation techniques, where the assumed presence of censored information facilitates a simpler parameterization. Then the expectation-maximization algorithm is used to estimate the parameters in the model. The performance of the proposed method is evaluated by numerical studies. Finally, the method is employed to analyze a dataset on tracking the advancement of coronary allograft vasculopathy following heart transplantation.

Indexed as

AlgorithmsHeart TransplantationProportional Hazards ModelsComputer SimulationData Interpretation, StatisticalHumansLikelihood FunctionsLongitudinal StudiesModels, Statisticaldata augmentationinterval censoringmultistate modelproportional hazards modeltime‐to‐event data

Identifiers

PMID38599784
PMCPMC11109708

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.