Evidence map›Paper›PMID 38599651›Full record

ArticleRMD open2024

Distinctive profile of monomeric and polymeric anti-SSA/Ro52 immunoglobulin A1 isoforms in saliva of patients with primary Sjögren's syndrome and Sicca.

Samantha Chiang, Tristan Grogan, Sarah Kamounah, Fang Wei, Nabihah Tayob, Ju Yeon Kim, Jin Kyun Park, David Akin, David A Elashoff, Anne Marie Lynge Pedersen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Samantha ChiangUCLA School of Dentistry, Los Angeles, California, USA.
Tristan GroganDepartment of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, California, USA.
Sarah KamounahOral Biology and Immunopathology/Oral Medicine & Pathology, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen N, Denmark.
Fang WeiUCLA School of Dentistry, Los Angeles, California, USA.
Nabihah TayobData Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Ju Yeon KimRheumatology, Seoul National University Hospital, Seoul, Korea.
Jin Kyun ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
David AkinUCLA School of Dentistry, Los Angeles, California, USA.
David A ElashoffDepartment of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, California, USA.
Anne Marie Lynge PedersenSection for Oral Biolology and Immunopathology, Oral Medicine and Pathology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark ysong@snu.ac.kr amlp@sund.ku.dk dtww@ucla.edu dchia@mednet.ucla.edu.
Yeong Wook SongDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea ysong@snu.ac.kr amlp@sund.ku.dk dtww@ucla.edu dchia@mednet.ucla.edu.ORCID 0000-0002-5384-3437
David T W WongUCLA School of Dentistry, Los Angeles, California, USA ysong@snu.ac.kr amlp@sund.ku.dk dtww@ucla.edu dchia@mednet.ucla.edu.
David ChiaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA ysong@snu.ac.kr amlp@sund.ku.dk dtww@ucla.edu dchia@mednet.ucla.edu.ORCID 0000-0002-0723-3670
University of California, Los Angeles · USSeoul National University · KRUniversity of Copenhagen · DKDana-Farber Cancer Institute · USSeoul National University Hospital · KR

Funding

Salivary Biomarkers for Sjogren's Syndrome Detection-Definitive ValidationU01DE017593 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2011 to 2014
$4.3M
Immunoregulatory role of saliva polymeric IgA1 in the pathogenesis of primary Sjögren’s SyndromeR03DE030990 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2021 to 2022
$312k
NIDCR NIH HHS R03 DE030990NIDCR NIH HHS U01 DE017593
6 · The paper itself

Abstract

objectivePrimary Sjögren's syndrome (pSS) is the second most common chronic autoimmune connective tissue disease. Autoantibodies, immunoglobulin (IgG) anti-SSA/Ro, in serum is a key diagnostic feature of pSS. Since pSS is a disease of the salivary gland, we investigated anti-SSA/Ro52 in saliva.

methodsUsing a novel electrochemical detection platform, Electric Field-Induced Release and Measurement, we measured IgG/M/A, IgG, IgA, IgA isotypes (IgA1 and IgA2) and IgA1 subclasses (polymeric and monomeric IgA1) to anti-SSA/Ro52 in saliva supernatant of 34 pSS, 35 dry eyes and dry mouth (patients with Sicca) and 41 health controls.

resultsSaliva IgG/M/A, IgG, IgA, IgA isotypes and IgA1 subclasses to anti-SSA/Ro52 differed significantly between pSS, non-pSS Sicca and healthy subjects. Elevated monomeric IgA1 was observed in patients with non-pSS Sicca while elevated polymeric IgA1 (pIgA1) was observed in patients with pSS. Salivary polymeric but not monomeric IgA1 (mIgA1) isoform correlated with focus score (r2=0.467, p=0.001)

conclusionsSalivary anti-Ro52 polymeric IgA1 isoform is associated with glandular inflammation in pSS, while salivary monomeric IgA1 is associated with Sicca. Whether IgA1 isotope switching plays a role in the progression of the Sicca to pSS warrants further investigation.

Indexed as

SalivaSjogren's SyndromeAutoantibodiesHumansImmunoglobulin AImmunoglobulin GAutoantibodiesImmunoglobulin AImmunoglobulin GAutoantibodiesAutoimmune DiseasesAutoimmunitySjogren's Syndrome

Identifiers

PMID38599651
PMCPMC11015269
OpenAlexW4394680407

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.