Evidence map›Paper›PMID 38599510›Full record

ArticleBrain research2024

Manipulation of α4βδ GABA

Sheryl S Smith, Safae Benanni, Quiana Jones, Lindsay Kenney, Matthew R Evrard

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sheryl S SmithDepartment of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY 11203, USA. Electronic address: sheryl.smith@downstate.edu.
Safae BenanniDepartment of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY 11203, USA. Electronic address: bsafae.benanni@downstate.edu.
Quiana JonesDepartment of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY 11203, USA. Electronic address: cquiana.jones@downstate.edu.
Lindsay KenneyDepartment of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY 11203, USA. Electronic address: dlindsay.kenney@downstate.edu.
Matthew R EvrardDepartment of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY 11203, USA. Electronic address: ematthew.evrard.ctr@usuhs.edu.
SUNY Downstate Health Sciences University · US

Funding

Effect of GABAergic inhibition of dendritic spines on synaptic pruning in the medial prefrontal cortex during adolescenceR01MH115900 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI SMITH, SHERYL S · 2019 to 2023
$3.2M
NIMH NIH HHS R01 MH115900
6 · The paper itself

Abstract

Temporal order memory is impaired in autism spectrum disorder (ASD) and schizophrenia (SCZ). These disorders, more prevalent in males, result in abnormal dendritic spine pruning during adolescence in layer 3 (L3) medial prefrontal cortex (mPFC), yielding either too many (ASD) or too few (SCZ) spines. Here we tested whether altering spine density in neural circuits including the mPFC could be associated with impaired temporal order memory in male mice. We have shown that α4βδ GABA

Indexed as

Autism Spectrum DisorderNeuronal PlasticityPrefrontal CortexPyramidal CellsReceptors, GABA-ASchizophreniaAnimalsMaleMice, Inbred C57BLMice, KnockoutReceptors, GABA-AAlpha4-beta-delta GABA(A) receptorAutism spectrum disorderDendritic spinePrelimbic prefrontal cortexSchizophreniaTemporal order memory

Identifiers

PMID38599510
PMCPMC12452088
OpenAlexW4394566493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.