Evidence map›Paper›PMID 38599280›Full record

ArticleJournal of vascular and interventional radiology : JVIR2024

Image-Guided Transbronchial Pulmonary Cryoablation with a Flexible Cryoprobe in Swine: Performance and Radiology-Pathology Correlation.

Quirina M B de Ruiter, Michal M Mauda-Havakuk, Matthew F Starost, Ivane Bakhutashvili, Juan A Esparza-Trujillo, Andrew Brown, Harishankar Natesan, Graig Kveen, Andrew L Lewis, Bradford J Wood and 2 more

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of vascular and interventional radiology : JVIR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Opportunities for Interventional Radiology in Transbronchial Interventions.Cardiovascular and interventional radiology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Quirina M B de RuiterCenter for Interventional Oncology, Radiology & Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Michal M Mauda-HavakukCenter for Interventional Oncology, Radiology & Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland; Interventional Radiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Matthew F StarostDivision of Veterinary Resources, National Institutes of Health, Bethesda, Maryland.
Ivane BakhutashviliCenter for Interventional Oncology, Radiology & Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Juan A Esparza-TrujilloCenter for Interventional Oncology, Radiology & Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Andrew BrownBoston Scientific (formerly BTG), Arden Hills, Minnesota.
Harishankar NatesanBoston Scientific (formerly BTG), Arden Hills, Minnesota.
Graig KveenBoston Scientific (formerly BTG), Arden Hills, Minnesota.
Andrew L LewisBoston Scientific (formerly BTG), Arden Hills, Minnesota; Alchemed Bioscience Consulting Ltd, Farnham, Surrey, United Kingdom.
Bradford J WoodCenter for Interventional Oncology, Radiology & Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland; Center for Cancer Research, National Institutes of Health, Bethesda, Maryland.
William F PritchardCenter for Interventional Oncology, Radiology & Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland.
John W KaranianCenter for Interventional Oncology, Radiology & Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland. Electronic address: john.karanian@nih.gov.

Funding

Center for Interventional OncologyZIDBC011242 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WOOD, BRADFORD J · 2009 to 2025
$18.7M
Navigation Tools for Image Guided Minimally invasive TherapiesZIACL040011 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
Interventional OncologyZIACL040015 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
Intramural NIH HHS Z99 CL999999Intramural NIH HHS ZIA CL040015
6 · The paper itself

Abstract

purposeTo evaluate the performance of a prototype flexible transbronchial cryoprobe compared with that of percutaneous transthoracic cryoablation and to define cone-beam computed tomography (CT) imaging and pathology cryolesion features in an in vivo swine model. MATERIALS AND

methodsTransbronchial cryoablation was performed with a prototype flexible cryoprobe (3 central and 3 peripheral lung ablations in 3 swine) and compared with transthoracic cryoablation performed with a commercially available rigid cryoprobe (2 peripheral lung ablations in 1 swine). Procedural time and cryoablation success rates for endobronchial navigation and cryoneedle deployment were measured. Intraoperative cone-beam CT imaging features of cryolesions were characterized and correlated with gross pathology and hematoxylin and eosin-stained sections of the explanted cryolesions.

resultsThe flexible cryoprobe was successfully navigated and delivered to each target through a steerable guiding sheath (6/6). At 4 minutes after ablation, 5 of 6 transbronchial and 2 of 2 transthoracic cryolesions were visible on cone-beam CT. The volumes on cone-beam CT images were 55.5 cm

conclusionsTransbronchial cryoablation with a flexible cryoprobe, delivered through a steerable guiding sheath, is feasible. Transbronchial cryoablation zones are imageable with cone-beam CT, with gross pathology and histopathology similar to those of transthoracic cryoablation.

Indexed as

Cone-Beam Computed TomographyCryosurgeryEquipment DesignAnimalsBronchoscopyLungModels, AnimalRadiography, InterventionalSus scrofaSwine

Identifiers

PMID38599280
PMCPMC11194150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.