Evidence map›Paper›PMID 38598701›Full record

ArticleBiomacromolecules2024

In Situ Synthesis and Self-Assembly of Peptide-PEG Conjugates: A Facile Method for the Construction of Fibrous Hydrogels.

Haritha Asokan-Sheeja, Kamal Awad, Jiazhu Xu, Myan Le, Jenny N Nguyen, Na Nguyen, Tam P Nguyen, Kytai T Nguyen, Yi Hong, Venu G Varanasi and 2 more

Abstract read
In one paragraph

Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haritha Asokan-SheejaDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Kamal AwadBone Muscle Research Center, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Jiazhu XuDepartment of Bioengineering, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Myan LeDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Jenny N NguyenDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Na NguyenDepartment of Bioengineering, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Tam P NguyenDepartment of Bioengineering, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Kytai T NguyenDepartment of Bioengineering, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Yi HongDepartment of Bioengineering, The University of Texas at Arlington, Arlington, Texas 76019, United States.ORCID 0000-0002-5846-2596
Venu G VaranasiBone Muscle Research Center, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Xiaohua LiuDepartment of Chemical and Biomedical Engineering, The University of Missouri, Columbia, Missouri 65211, United States.ORCID 0000-0003-0177-0886
He DongDepartment of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.ORCID 0000-0002-8494-0475

Funding

Semiconductor Biomaterials to Speed Bone Healing: A Bioengineering-Driven ApproachR01DE031872 · NIDCR · UNIVERSITY OF TEXAS ARLINGTON · PI Venu Gopal Varanasi · 2023 to 2026
$1.8M
NIDCR NIH HHS R01 DE031872
6 · The paper itself

Abstract

Peptide-based hydrogels have gained considerable attention as a compelling platform for various biomedical applications in recent years. Their attractiveness stems from their ability to seamlessly integrate diverse properties, such as biocompatibility, biodegradability, easily adjustable hydrophilicity/hydrophobicity, and other functionalities. However, a significant drawback is that most of the functional self-assembling peptides cannot form robust hydrogels suitable for biological applications. In this study, we present the synthesis of novel peptide-PEG conjugates and explore their comprehensive hydrogel properties. The hydrogel comprises double networks, with the first network formed through the self-assembly of peptides to create a β-sheet secondary structure. The second network is established through covalent bond formation via

Indexed as

Biomedical TechnologyHydrogelsPeptidesPolyethylene GlycolsAntimicrobial PeptidesCell LineCell SurvivalEscherichia coliFibroblastsHumansRheologyAntimicrobial PeptidesHydrogelsPeptidesPolyethylene Glycols

Identifiers

PMID38598701
PMCPMC11867594

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.