ArticlePloS one2024
Prevalence, genetic diversity and eco-epidemiology of pathogenic Leptospira species in small mammal communities in urban parks Lyon city, France.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Systematic review of the prevalence of environmental and host-related risk factors and the zoonotic potential of leptospirosis in domestic dogs in regions impacted by environmental changes.BMC veterinary research · 2025Pooled it
- Small rodents, huge impact: A scoping review of EuropeanOne health (Amsterdam, Netherlands) · 2026Review
- Longitudinal Survey of Pathogenic Leptospira Species at a Major Park in Sydney, Australia.EcoHealth · 2026Article
- Artificial Irrigation Impacts the Seasonal Occurrence of Pathogenic Leptospira in Its Wild Reservoirs in a Mediterranean Environment.Zoonoses and public health · 2026Article
- Genotyping Reveals Potential Sources of Human Leptospirosis Outbreaks in Aotearoa New Zealand.Zoonoses and public health · 2026Article
- Serological and molecular evidence of Leptospira spp. in martens from Poland.BMC veterinary research · 2026Article
- Leptospirosis in Southeast Asia: Investigating Seroprevalence, Transmission Patterns, and Diagnostic Challenges.Tropical medicine and infectious disease · 2026Review
- Surveillance of Zoonotic Pathogens in Small Mammals Across Forests With Different Levels of Anthropization in Eastern France.Transboundary and emerging diseases · 2026Article
- Host-Driven Genetic Diversity ofTransboundary and emerging diseases · 2026Article
- Molecular detection of a Leptospira lineage with high similarity to Leptospira kirschneri in human, environmental, and rodent samples from Gilan Province, Iran: an integrated field and laboratory investigation.GMS hygiene and infection control · 2026Article
- A Guidance for Diagnosis, Control Measures, and Surveillance of Leptospirosis in Non-Human Primates From a Veterinary Perspective in a One-Health Approach.Journal of medical primatology · 2025Review
- DNA metabarcoding analysis revealed a silent prevalence of environmental pathogenicOne health (Amsterdam, Netherlands) · 2025Article
- Chronic Carriage of Leptospira interrogans Genotype Associated With the Australis Serogroup by Naturally-Infected Hedgehogs ( Erinaceus europaeus ) at a Wildlife Health Centre in Northwestern France.Zoonoses and public health · 2025Article
- Diversity ofMicroorganisms · 2025Article
- Seroprevalence and carrier status ofIranian journal of veterinary research · 2025Article
- The Relationship Between the Spatial Occurrence ofPathogens (Basel, Switzerland) · 2024Article
- Characterisation of pathogenicEpidemiology and infection · 2024Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rodents are recognized as the main reservoirs of Leptospira spp. Rats, in particular, serve as hosts for the widely predominant Leptospira interrogans serovar Icterohaemorrhagiae, found worldwide. Several studies have shown the importance of other reservoirs, such as mice or hedgehogs, which harbor other leptospires' serovars. Nevertheless, our knowledge of circulating Leptospira spp. in reservoirs other than rats remains limited. In this context, we proposed an eco-health approach to assess the health hazard associated with leptospires in urban green spaces, where contacts between human/small mammals and domestic animals are likely. We studied the prevalence, the diversity of circulating strains, and epidemiology of pathogenic Leptospira species in small terrestrial mammal communities (rodents and shrews), between 2020-2022, in two parks in Lyon metropolis, France. Our study showed a significant carriage of Leptospira spp. in small terrestrial mammals in these parks and unveiled a global prevalence rate of 11.4%. Significant variations of prevalence were observed among the small mammal species (from 0 to 26.1%), with Rattus norvegicus exhibiting the highest infection levels (26.1%). We also observed strong spatio-temporal variations in Leptospira spp. circulation in its reservoirs. Prevalence seems to be higher in the peri-urban park and in autumn in 2021 and 2022. This is potentially due to differences in landscape, abiotic conditions and small mammal communities' composition. Our study suggests an important public health relevance of rats and in a lesser extent of other rodents (Apodemus spp., Clethrionomys glareolus and Mus musculus) as reservoirs of L. interrogans, with rodent species carrying specific serogroups/serovars. We also emphasize the potential hazard associated between the shrew Crocidura russula and L. kirschneri. Altogether, these results improve our knowledge about the prevalence of leptospirosis in an urban environment, which is an essential prerequisite for the implementation of prevention of associated risks.
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