Evidence map›Paper›PMID 38598312›Full record

ArticleJournal of medicinal chemistry2024

Potentiating Activity of GmhA Inhibitors on Gram-Negative Bacteria.

François Moreau, Dmytro Atamanyuk, Markus Blaukopf, Marek Barath, Mihály Herczeg, Nuno M Xavier, Jérôme Monbrun, Etienne Airiau, Vivien Henryon, Frédéric Leroy and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 7 countries.

François MoreauMutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.
Dmytro AtamanyukMutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.
Markus BlaukopfDepartment of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.
Marek BarathDepartment of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.
Mihály HerczegDepartment of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.ORCID 0000-0002-7938-9789
Nuno M XavierDepartment of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.ORCID 0000-0001-8739-8768
Jérôme MonbrunActivation, 10 Rue Jacquard, Chassieu 69680, France.
Etienne AiriauActivation, 10 Rue Jacquard, Chassieu 69680, France.
Vivien HenryonActivation, 10 Rue Jacquard, Chassieu 69680, France.
Frédéric LeroyCarbosynth Limited, 8&9 Old Station Business Park, Compton, Berkshire RG20 6NE, U.K.
Stéphanie FloquetMutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.
Damien BonnardMutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.
Robert SzablaDepartment of Biochemistry, University of Western Ontario, London, ON N6A 3K7, Canada.
Chris BrownDepartment of Biochemistry, University of Western Ontario, London, ON N6A 3K7, Canada.
Murray S JunopDepartment of Biochemistry, University of Western Ontario, London, ON N6A 3K7, Canada.ORCID 0000-0001-6676-5717
Paul KosmaDepartment of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna A-1190, Austria.ORCID 0000-0001-5342-7161
Vincent GeruszMutabilis, 102 Avenue Gaston Roussel, Romainville 93230, France.
Mutabilis (France) · FRWestern University · CABOKU University · ATInstitute of Chemistry of the Slovak Academy of Sciences · SKNewbury College · USUniversity of Debrecen · HUUniversity of Lisbon · PT

Funding

CIHR
6 · The paper itself

Abstract

Inhibition of the biosynthesis of bacterial heptoses opens novel perspectives for antimicrobial therapies. The enzyme GmhA responsible for the first committed biosynthetic step catalyzes the conversion of sedoheptulose 7-phosphate into d-

Indexed as

Anti-Bacterial AgentsCrystallography, X-RayDrug SynergismEnzyme InhibitorsEscherichia coliFormatesGram-Negative BacteriaHep G2 CellsHumansHydroxamic AcidsMicrobial Sensitivity TestsModels, MolecularStructure-Activity RelationshipZincAnti-Bacterial AgentsEnzyme InhibitorsFormatesHydroxamic AcidsN-formyl hydroxamateZinc

Identifiers

PMID38598312
PMCPMC11056994
OpenAlexW4394675542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.