Evidence map›Paper›PMID 38598087›Full record

ArticleJournal of neuro-oncology2024

Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by boron neutron capture therapy.

Natsuko Kondo, Tadatoshi Kinouchi, Manabu Natsumeda, Juntaro Matsuzaki, Eishu Hirata, Yoshinori Sakurai, Masayasu Okada, Minoru Suzuki

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Natsuko KondoParticle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori, Sennan-gun, Osaka, 590-0494, Japan. kondo.natsuko.3x@kyoto-u.ac.jp.
Tadatoshi KinouchiDivision of Radiation Biochemistry, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori, Sennan-gun, Osaka, 590-0494, Japan.
Manabu NatsumedaDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Juntaro MatsuzakiDivision of Pharmacotherapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Eishu HirataDivision of Tumor Cell Biology and Bioimaging, Cancer Research Institute of Kanazawa University, Kanazawa, Japan.
Yoshinori SakuraiParticle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori, Sennan-gun, Osaka, 590-0494, Japan.
Masayasu OkadaDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Minoru SuzukiParticle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori, Sennan-gun, Osaka, 590-0494, Japan.
Kyoto University · JPNiigata University · JPKanazawa University · JPKeio University · JP

Funding

Japan Society for the Promotion of Science 21K09151
6 · The paper itself

Abstract

purposeBoron neutron capture therapy (BNCT) is a tumor cell-selective particle-radiation therapy. In BNCT, administered p-boronophenylalanine (BPA) is selectively taken up by tumor cells, and the tumor is irradiated with thermal neutrons. High-LET α-particles and recoil

methodGlioblastoma U87 MG cells were treated with 25 ppm of BPA in the culture media and irradiated with thermal neutrons. After irradiation, they were plated into dishes and cultured for 3 days in the 5% CO

resultAn increase in 20 individual miRNAs (ratio > 2) and a decrease in 2 individual miRNAs (ratio < 0.5) were detected in BNCT cells compared with non-irradiated cells. Among detected miRNAs, 20 miRNAs were associated with worse prognosis of glioma in Kaplan Meier Survival Analysis of overall survival in TCGA.

conclusionThese miRNA after BNCT may proceed tumors, modulate radiation resistance, or inhibit invasion and affect the prognosis of glioma.

Indexed as

Boron Neutron Capture TherapyBrain NeoplasmsExtracellular VesiclesGlioblastomaMicroRNAsCell Line, TumorGene Expression Regulation, NeoplasticHumansMicroRNAsGlioblastomaMicroarray and boron neutron capture therapyMicroRNASmall extracellular vesicles

Identifiers

PMID38598087
OpenAlexW4394685806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.