ArticleEuropean journal of nutrition2024
Association between dietary magnesium intake, inflammation, and neurodegeneration.
Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- The association of long-term air pollution with a composite neurodegenerative risk score among Chinese elderly: evidence from the CHARLS.Environmental health : a global access science source · 2026Article
- Magnesium Status in Celiac Disease: Potential Links with Neuroinflammatory Pathways and Gut-Brain Axis Dysfunction.International journal of molecular sciences · 2026Review
- Adjunctive Intravenous Magnesium Sulfate for Postoperative Pain and Opioid Reduction in Lower Extremity Orthopedic Surgery: A Double-Blind Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Association between low magnesium status and new-onset dementia in the general population: a propensity score-matched cohort study.Frontiers in nutrition · 2026Article
- Associations of magnesium intake and a magnesium-rich diet score with sarcopenia in middle-aged and older Korean adults: potential mediation by C-reactive protein.Frontiers in nutrition · 2026Article
- Dietary magnesium intake and dementia risk in community-dwelling people aged 40-74 years: an 8-year cohort study.Journal of nutritional science · 2026Article
- Carotid intraplaque neovascularization increases the risk of white matter hyperintensity progression: a prospective cohort study.Frontiers in neuroscience · 2026Article
- The association between magnesium intake and circadian syndrome among US adults attending NHANES 2005-2016.Nutrition journal · 2025Article
- Review
- The Role of Magnesium in Depression, Migraine, Alzheimer's Disease, and Cognitive Health: A Comprehensive Review.Nutrients · 2025Review
- Article
- Dietary inflammatory potential, genetic susceptibility, and systemic inflammation indices in relation to abdominal aortic aneurysm risk: a prospective cohort study.Frontiers in nutrition · 2025Article
- The association between magnesium levels and gout: evidence from Mendelian randomization, a Chinese cross-sectional study, and NHANES analysis.Frontiers in nutrition · 2025Article
- High Blood Pressure and Impaired Brain Health: Investigating the Neuroprotective Potential of Magnesium.International journal of molecular sciences · 2024Review
- Review
- Acetyltransferase in cardiovascular disease and aging.The journal of cardiovascular aging · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsistent evidence shows that magnesium (Mg) intake is associated with lower blood pressure (BP), and that lower BP is associated with improved cerebral health. However, recent findings indicate that the positive effect of dietary Mg intake on cerebral health is not mediated by a decrease in BP. As Mg's anti-inflammatory action is a plausible alternative mechanism, the objective of this study was to investigate the associations between Mg intake and inflammation to determine whether it mediates any neuroprotective effect.
methodsParticipants from the UK Biobank (n = 5775, aged 40-73 years, 54.7% female) were assessed for dietary magnesium using an online food questionnaire, brain and white matter lesion (WML) volumes were segmented with FreeSurfer software, and inflammation markers including high-sensitivity C-reactive protein (hs-CRP), leukocyte, erythrocyte count, and Glycoprotein acetylation (GlycA) were measured using specific laboratory techniques such as immunoturbidimetry, automated cell counting, and nuclear magnetic resonance. Hierarchical linear regression models were performed to investigate the association between dietary Mg, and inflammatory markers and between dietary Mg, brain and WMLs volumes. Mediation analysis was performed to test a possible mediation role of inflammation on the association between dietary Mg and brain and WMLs volumes.
resultsHigher dietary Mg intake was associated with lower inflammation: hs-CRP level (- 0.0497%; 95% confidence interval [CI] - 0.0497%, - 0.0199%) leukocytes count (- 0.0015%; 95%CI - 0.00151%, - 0.0011%), and GlycA (- 0.0519%; 95%CI - 0.1298%, - 0.0129%). Moreover, higher dietary Mg intake was associated with larger grey matter volume (0.010%; 95%CI 0.004%, 0.017%), white matter volume (0.012%; 95%CI 0.003, 0.022) and right hippocampal volume (0.002%; 95%CI 0.0007, -0.0025%). Lower hs-CRP levels mediated the positive association between higher dietary Mg intake and larger grey matter volume.
conclusionsThe anti-inflammatory effects of dietary Mg intake in the general population, appears to mediate its neuroprotective effect.
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