Evidence map›Paper›PMID 38597936›Full record

ArticleCellular and molecular life sciences : CMLS2024

CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice.

Hongbin Zhou, Zhihua Zhang, Ronggui Qu, Hongying Zhu, Yuxi Luo, Qun Li, Jian Mu, Ran Yu, Yang Zeng, Biaobang Chen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hongbin Zhou *Institute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Zhihua Zhang *Institute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Ronggui QuInstitute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Hongying ZhuInstitute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Yuxi LuoInstitute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Qun LiInstitute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Jian MuInstitute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Ran YuInstitute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Yang ZengInstitute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China.
Biaobang ChenNHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, 200032, China.
Qing SangInstitute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China. sangqing@fudan.edu.cn.ORCID http://orcid.org/0000-0002-9895-1394
Lei WangInstitute of Pediatrics, The Institutes of Biomedical Sciences, The State Key Laboratory of Genetic Engineering, School of Life Sciences, Children's Hospital of Fudan University, Fudan University, Shanghai, 200032, China. wangleiwanglei@fudan.edu.cn.
Children's Hospital of Fudan University · CNFudan University · CN

Funding

the National Key Research and Development Program for Young Scientists 2022YFC2702300the National Natural Science Foundation of China 82201767the Project of the Shanghai Municipal Science and Technology Commission 21XD1420300the Project of the Shanghai Municipal Science and Technology Commission 21YF1418300
6 · The paper itself

Abstract

Mature spermatozoa with normal morphology and motility are essential for male reproduction. The epididymis has an important role in the proper maturation and function of spermatozoa for fertilization. However, factors related to the processes involved in spermatozoa modifications are still unclear. Here we demonstrated that CCDC28A, a member of the CCDC family proteins, is highly expressed in testes and the CCDC28A deletion leads to male infertility. We found CCDC28A deletion had a mild effect on spermatogenesis. And epididymal sperm collected from Ccdc28a

Indexed as

Infertility, MaleSperm MotilityAnimalsHumansMaleMiceSemenSpermatozoaSperm HeadCCDC28AKnockoutMale infertilityMotilitySperm head defects

Identifiers

PMID38597936
PMCPMC11006775
OpenAlexW4394691027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.