Evidence map›Paper›PMID 38597844›Full record

ReviewJACC. Cardiovascular interventions2024

Chronological vs Biological Age in Interventional Cardiology: A Comprehensive Approach to Care for Older Adults: JACC Family Series.

Abdulla A Damluji, Michael G Nanna, Jennifer Rymer, Ajar Kochar, Angela Lowenstern, Suzanne J Baron, Craig R Narins, Mohamad Alkhouli

Open access · greenAbstract readReview
In one paragraph

Review in JACC. Cardiovascular interventions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  12. Drug-Coated Balloons for Coronary Artery Disease: From Theory to Practice.Current treatment options in cardiovascular medicine · 2025
    Article
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  20. The Impact of Cognitive Impairment on Cardiovascular Disease.Journal of the American College of Cardiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 1 country.

Abdulla A DamlujiInova Center of Outcomes Research, Fairfax, Virginia, USA; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Michael G NannaYale University School of Medicine, New Haven, Connecticut, USA.
Jennifer RymerDuke University School of Medicine, Durham, North Carolina USA.
Ajar KocharBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Angela LowensternVanderbilt University Medical Center, Nashville, Tennessee, USA.
Suzanne J BaronMassachusetts General Hospital, Boston, Massachusetts, USA.
Craig R NarinsUniversity of Rochester, Rochester, New York, USA.
Mohamad AlkhouliMayo Clinic School of Medicine, Rochester, Minnesota, USA. Electronic address: alkhouli.mohamad@mayo.edu.
Brigham and Women's Hospital · USDuke University · USJohns Hopkins University · USMassachusetts General Hospital · USMayo Clinic · USUniversity of Rochester · USVanderbilt University Medical Center · USYale University · US

Funding

Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Lauren Ferrante · 2002 to 2026
$37.9M
Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Physical Rehabilitation for Older Patients with Acute HFpEF-The REHAB-HFpEF TrialR01AG078153 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2022 to 2025
$26.6M
Frailty and Resiliency in Older Adults with Acute Myocardial InfarctionK23HL153771 · NHLBI · INOVA HEALTH CARE SERVICES · PI DAMLUJI, ABDULLA AL · 2020 to 2024
$916k
Generating novel predictive models to estimate the risk of future ASCVD & Dementia in older adultsR03AG074067 · NIA · YALE UNIVERSITY · PI NANNA, MICHAEL · 2021 to 2022
$335k
NHLBI NIH HHS K23 HL153771NIA NIH HHS P30 AG021334NIA NIH HHS P30 AG021342NIA NIH HHS R01 AG078153NIA NIH HHS R03 AG074067
6 · The paper itself

Abstract

Aging is the gradual decline in physical and physiological functioning leading to increased susceptibility to stressors and chronic illnesses, including cardiovascular disease. With an aging global population, in which 1 in 6 individuals will be older than 60 years by 2030, interventional cardiologists are increasingly involved in providing complex care for older individuals. Although procedural aspects remain their main clinical focus, interventionalists frequently encounter age-associated risks that influence eligibility for invasive care, decision making during the intervention, procedural adverse events, and long-term management decisions. The unprecedented growth in transcatheter interventions, especially for structural heart diseases at extremes of age, have pushed age-related risks and implications for cardiovascular care to the forefront. In this JACC state-of-the-art review, the authors provide a comprehensive overview of the aging process as it relates to cardiovascular interventions, with special emphasis on the difference between chronological and biological aging. The authors also address key considerations to improve health outcomes for older patients during and after their invasive cardiovascular care. The role of "gerotherapeutics" in interventional cardiology, technological innovation in measuring biological aging, and the integration of patient-centered outcomes in the older adult population are also discussed.

Indexed as

AgingCardiovascular DiseasesAgedAged, 80 and overAge FactorsCardiac CatheterizationCardiologyFemaleGeriatric AssessmentHumansMaleMiddle AgedRisk AssessmentRisk FactorsTreatment Outcomeage-associated risksagingcardiovascular diseaserisk factorstranscatheter therapeutics

Identifiers

PMID38597844
PMCPMC11097960
OpenAlexW4394582273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.