Evidence map›Paper›PMID 38597785›Full record

ArticleRadiology. Artificial intelligence2024

A Semiautonomous Deep Learning System to Reduce False Positives in Screening Mammography.

Stefano Pedemonte, Trevor Tsue, Brent Mombourquette, Yen Nhi Truong Vu, Thomas Matthews, Rodrigo Morales Hoil, Meet Shah, Nikita Ghare, Naomi Zingman-Daniels, Susan Holley and 3 more

Abstract read
In one paragraph

Article in Radiology. Artificial intelligence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stefano PedemonteFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).
Trevor TsueFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).ORCID 0000-0001-6880-8872
Brent MombourquetteFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).ORCID 0000-0002-1793-0197
Yen Nhi Truong VuFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).
Thomas MatthewsFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).ORCID 0000-0002-9365-6812
Rodrigo Morales HoilFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).ORCID 0000-0002-0573-8587
Meet ShahFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).
Nikita GhareFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).ORCID 0000-0002-2315-0576
Naomi Zingman-DanielsFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).ORCID 0009-0004-6345-8040
Susan HolleyFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).
Catherine M AppletonFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).
Jason SuFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).ORCID 0000-0001-5987-1108
Richard L WahlFrom Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).ORCID 0000-0002-7306-2590

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To evaluate the ability of a semiautonomous artificial intelligence (AI) model to identify screening mammograms not suspicious for breast cancer and reduce the number of false-positive examinations. Materials and Methods The deep learning algorithm was trained using 123 248 two-dimensional digital mammograms (6161 cancers) and a retrospective study was performed on three nonoverlapping datasets of 14 831 screening mammography examinations (1026 cancers) from two U.S. institutions and one U.K. institution (2008-2017). The stand-alone performance of humans and AI was compared. Human plus AI performance was simulated to examine reductions in the cancer detection rate, number of examinations, false-positive callbacks, and benign biopsies. Metrics were adjusted to mimic the natural distribution of a screening population, and bootstrapped CIs and

Indexed as

Breast NeoplasmsDeep LearningMammographyAdultAgedEarly Detection of CancerFalse Positive ReactionsFemaleHumansMiddle AgedRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesUnited StatesArtificial IntelligenceBreast CancerScreening MammograpSemiautonomous Deep Learning

Identifiers

PMID38597785
PMCPMC11140506

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.