Evidence map›Paper›PMID 38597659›Full record

ArticleEndocrinology2024

Puberty Blocker, Leuprolide, Reduces Sex Differences in Rough-and-Tumble Play and Anxiety-like Behavior in Juvenile Rats.

Gabriela de Faria Oliveira, Amber T Nguyen, Leykza Carreras-Simons, Thomas Niepsuj, Salma H Gadelhak, Aimee K Johnson, Ashwakh Abdalla, Eden Lev, Sofia G Torres Román, Samantha N Fuchs and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Gabriela de Faria OliveiraWisconsin National Primate Research Center, Madison, WI 53715, USA.ORCID 0000-0002-0498-0312
Amber T NguyenDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Leykza Carreras-SimonsDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Thomas NiepsujDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Salma H GadelhakDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Aimee K JohnsonDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Ashwakh AbdallaDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Eden LevDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Sofia G Torres RománDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Samantha N FuchsDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Joan S JorgensenDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-5787-8856
Walid A FarhatDivision of Pediatric Urology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Anthony P AugerDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
University of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
NIH HHS P51 OD011106University of Wisconsin School of Medicine and Public HealthWisconsin Partnership Program
6 · The paper itself

Abstract

We examined the effect of the puberty blocker, leuprolide acetate, on sex differences in juvenile rough-and-tumble play behavior and anxiety-like behavior in adolescent male and female rats. We also evaluated leuprolide treatment on gonadal and pituitary hormone levels and activity-regulated cytoskeleton-protein messenger RNA levels within the adolescent amygdala, a region important both for rough-and-tumble play and anxiety-like behavior. Our findings suggest that leuprolide treatment lowered anxiety-like behavior during adolescent development, suggesting that the maturation of gonadotropin-releasing hormone systems may be linked to increased anxiety. These data provide a potential new model to understand the emergence of increased anxiety triggered around puberty. Leuprolide also reduced masculinized levels of rough-and-tumble play behavior, lowered follicle-stimulating hormone, and produced a consistent pattern of reducing or halting sex differences of hormone levels, including testosterone, growth hormone, thyrotropin, and corticosterone levels. Therefore, leuprolide treatment not only pauses sexual development of peripheral tissues, but also reduces sex differences in hormones, brain, and behavior, allowing for better harmonization of these systems following gender-affirming hormone treatment. These data contribute to the intended use of puberty blockers in stopping sex differences from developing further with the potential benefit of lowering anxiety-like behavior.

Indexed as

AnxietyBehavior, AnimalLeuprolideSexual MaturationAmygdalaAnimalsCorticosteroneFemaleMaleRatsRats, Sprague-DawleySex CharacteristicsTestosteroneCorticosteroneLeuprolideTestosteroneadolescentbehaviorGnRHleuprolidepuberty blockers

Identifiers

PMID38597659
PMCPMC11033216
OpenAlexW4394673654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.