Evidence map›Paper›PMID 38597443›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Saikosaponin a alleviates pentylenetetrazol-induced acute epileptic seizures in mouse models of depression by suppressing microglia activation-mediated inflammation].

Y Xiong, X Liang, X Liang, W Li, Y Qian, W Xie

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. [ModifiedNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Y XiongSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
X LiangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
X LiangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
W LiSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Y QianGuangzhou Liwan Gushengtang Traditional Chinese Medicine Clinic, Guangzhou 510250, China.
W XieSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the inhibitory effect of saikosonin a (SSa) on pentylenetetrazol-induced acute epilepsy seizures in a mouse model of depression and explore the mechanism mediating this effect.

methodsMale C57BL/6J mouse models of depression was established by oral administration of corticosterone

resultsThe mouse model of corticosterone-induced depression showed body weight loss and obvious depressive behaviors with significantly increased serum corticosterone level (all

conclusionDepressive state aggravates epileptic seizures, increases microglia activation, and elevates inflammation levels. SSA treatment can alleviate acute epileptic seizures in mouse models of depression possibly by suppressing microglia activation-mediated inflammation.

Indexed as

EpilepsyPentylenetetrazoleSaponinsAnimalsCorticosteroneDepressionDisease Models, AnimalHippocampusInflammationInterleukin-10Interleukin-1betaMaleMiceMice, Inbred C57BLMicrogliaOleanolic AcidCorticosteroneInterleukin-10Interleukin-1betaOleanolic AcidPentylenetetrazolesaikosaponin DSaponinsTumor Necrosis Factor-alphaanimal modelcomorbid depressionepilepsysaikosaponin a

Identifiers

PMID38597443
PMCPMC11006703
OpenAlexW4394763676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.