ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Racial discrimination during middle age predicts higher serum phosphorylated tau and neurofilament light chain levels a decade later: A study of aging black Americans.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Wearable Technology, Smart Home Systems, and Mobile Apps for the Self‑Management of Patient Outcomes in Dementia Care: Systematic Review.Journal of medical Internet research · 2025Pooled it
- Article
- Adverse policing as a social exposome pathway: Implications for depression, cognition, and dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Resilience Shields and Grit Intensifies Subjective Cognitive Decline in Middle-To-Older Aged Black Americans.International journal of geriatric psychiatry · 2026Article
- Associations of Longitudinal Changes in Blood Biomarkers of Dementia With the Proportion of Genetically Inferred African Ancestry.Neurology · 2025Article
- On the complexity of biomarker-driven diagnoses of Alzheimer's disease.Journal of neuropsychology · 2025Article
- Introducing social determinants of health to the Alzheimer's Disease Research Center network: Development and implementation in the Uniform Data Set.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Race and Incident Dementia Among Older Black and Older White Men.Journal of aging and health · 2025Article
- Biological aging and its association with serum neurofilament light chain levels in middle-aged African Americans: a prospective observational study.Aging advances · 2025Article
- Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures study.EClinicalMedicine · 2025Article
- Racial discrimination predicts subjective cognitive decline: Perceived relationship support buffers the association.Social science & medicine (1982) · 2024Article
- Alzheimer disease blood biomarkers: considerations for population-level use.Nature reviews. Neurology · 2024Review
- Racial discrimination during middle age predicts higher serum phosphorylated tau and neurofilament light chain levels a decade later: A study of aging black Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Population disparities in Alzheimer's disease: A systematic review of fluid and neuroimaging biomarkers.Alzheimer's & dementia (Amsterdam, Netherlands)Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionRecent evidence suggests that exposure to the stress of racism may increase the risk of dementia for Black Americans.
methodsThe present study used 17 years of data from a sample of 255 Black Americans to investigate the extent to which exposure to racial discrimination predicts subsequent changes in serum Alzheimer's Disease Research Center (ADRC) biomarkers: serum phosphorylated tau181(p-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP). We hypothesized that racial discrimination assessed during middle age would predict increases in these serum biomarkers as the participants aged into their 60s.
resultsOur findings indicate that exposure to various forms of racial discrimination during a person's 40s and early 50s predicts an 11-year increase in both serum p-tau181 and NfL. Racial discrimination was not associated with subsequent levels of GFAP. DISCUSSION: These findings suggest that racial discrimination in midlife may contribute to increased AD pathology and neurodegeneration later in life. HIGHLIGHTS: A 17-year longitudinal study of Black Americans. Assessments of change in serum p-tau181, neurofilament light, and glial fibrillary acidic protein. Exposure to racial discrimination during middle age predicted increases in p-tau181 and neurofilament light. Education was positively related to both p-tau181 and exposure to racial discrimination.
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