Evidence map›Paper›PMID 38596988›Full record

ArticleHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology2022

Effect of growth differentiation factor 11 on the steatosis of condylar chondrocytes in temporomandibular joint osteoarthritic mice.

Ruoxin Wang, Qian Liu, Feng He, Mian Zhang, Helin Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 67% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ruoxin WangSchool of Stomatology, Zhengzhou University, Zhengzhou 450052, China.
Qian LiuState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shanxi International Joint Research Center for Oral Diseases, Dept. of Oral Anatomy and Physiology, The Stomatological Hospital of the Fourth Military Medical University, Xi'an 710032, China.
Feng HeState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shanxi International Joint Research Center for Oral Diseases, Dept. of Oral Anatomy and Physiology, The Stomatological Hospital of the Fourth Military Medical University, Xi'an 710032, China.
Mian ZhangState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shanxi International Joint Research Center for Oral Diseases, Dept. of Oral Anatomy and Physiology, The Stomatological Hospital of the Fourth Military Medical University, Xi'an 710032, China.
Helin WangState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Dept. of Medical Rehabi-litation, The Stomatological Hospital of the Fourth Military Medical University, Xi'an 710032, China.
Air Force Medical University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo observe the effect of growth differentiation factor 11 (GDF11) on the steatosis of condylar chondrocytes in temporomandibular joint (TMJ) osteoarthritic mice.

methodsSix-week-old female C57 mice were stimulated with unilateral anterior crossbite (UAC) and locally injected with GDF11. TMJ sections were stained with safranin O, and GDF11 and Adiponectin in the TMJ cartilage were detected by immunohistochemical staining. GDF11, Adiponectin, type Ⅱ collagen (Col-Ⅱ), Aggrecan, type Ⅰ collagen (Col-Ⅰ), fatty acid-binding protein 4 (FABP4), and Perilipin 1 mRNA were detected by real-time polymerase chain reaction (real-time PCR).

resultsThe thickness and safranin O-positive area of TMJ cartilage in the UAC groups, as well as the mRNA expression of Col-Ⅱ and aggrecan, significantly decreased. The ratio of Adiponectin-positive cells significantly increased. The mRNA expression levels of Col-Ⅰ, Adiponectin, FABP4, and Perilipin 1 significantly increased. The TMJ cartilage of the GDF11 injection groups significantly thickened, and the safranin O-positive area significantly increased. The mRNA expression of Col-Ⅱ and Aggrecan significantly increased. The ratio of Adiponectin-positive cells significantly decreased. The mRNA expression levels of Col-I, Adiponectin, FABP4, and Perilipin 1 significantly decreased.

conclusionsExtensive steatosis of chondrocytes and decreased expression of GDF11 in the degenerated cartilage of TMJ osteoarthritis are induced by UAC stimulation. Supplementation of exogenous GDF11 can effectively inhibit the steatosis of chondrocytes.

Indexed as

chondrocytesgrowth differentiation factor 11osteoarthritissteatosistemporomandibular joint

Identifiers

PMID38596988
PMCPMC8905263
OpenAlexW4394768534

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.