Evidence map›Paper›PMID 38596821›Full record

ReviewIJID regions2024

Characterization of human respiratory syncytial virus in children with severe acute respiratory infection before and during the COVID-19 pandemic.

Paul Simusika, Michiko Okamoto, Clyde Dapat, Walter Muleya, Moffat Malisheni, Sikandar Azam, Takeaki Imamura, Mayuko Saito, Innocent Mwape, Evans Mpabalwani and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in IJID regions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Paul SimusikaTohoku University Graduate School of Medicine, Department of Virology, Sendai, Japan.
Michiko OkamotoTohoku University Graduate School of Medicine, Department of Virology, Sendai, Japan.
Clyde DapatTohoku University Graduate School of Medicine, Department of Virology, Sendai, Japan.
Walter MuleyaUniversity of Zambia, School of Veterinary Medicine, Department of Biomedical Sciences, Lusaka, Zambia.
Moffat MalisheniUniversity Teaching Hospitals, Pathology and Microbiology Department, Virology Laboratory, Lusaka, Zambia.
Sikandar AzamTohoku University Graduate School of Medicine, Department of Virology, Sendai, Japan.
Takeaki ImamuraTohoku University Graduate School of Medicine, Department of Virology, Sendai, Japan.
Mayuko SaitoTohoku University Graduate School of Medicine, Department of Virology, Sendai, Japan.
Innocent MwapeCenter for Infectious Disease Research in Zambia, Lusaka, Zambia.
Evans MpabalwaniUniversity of Zambia, School of Medicine, Department of Pediatrics and Child Health, Lusaka, Zambia.
Mwaka MonzeUniversity Teaching Hospitals, Pathology and Microbiology Department, Virology Laboratory, Lusaka, Zambia.
Hitoshi OshitaniTohoku University Graduate School of Medicine, Department of Virology, Sendai, Japan.
Tohoku University · JPUniversity of Zambia · ZMUniversity Teaching Hospital · ZMCentre for Infectious Disease Research in Zambia · ZM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Annual outbreaks of human respiratory syncytial virus (HRSV) are caused by newly introduced and locally persistent strains. During the COVID-19 pandemic, global and local circulation of HRSV significantly decreased. This study was conducted to characterize HRSV in 2018-2022 and to analyze the impact of COVID-19 on the evolution of HRSV. Design/methods: Combined oropharyngeal and nasopharyngeal swabs were collected from children hospitalized with severe acute respiratory infection at two hospitals in Zambia. The second hypervariable region of the attachment gene G was targeted for phylogenetic analysis. Results: Of 3113 specimens, 504 (16.2%) were positive for HRSV, of which 131 (26.0%) and 66 (13.1%) were identified as HRSVA and HRSVB, respectively. In early 2021, an increase in HRSV was detected, caused by multiple distinct clades of HRSVA and HRSVB. Some were newly introduced, whereas others resulted from local persistence. Conclusions: This study provides insights into the evolution of HRSV, driven by global and local circulation. The COVID-19 pandemic had a temporal impact on the evolution pattern of HRSV. Understanding the evolution of HRSV is vital for developing strategies for its control.

Indexed as

Molecular evolutionRespiratory syncytial virusSevere acute respiratory infectionZambia

Identifiers

PMID38596821
PMCPMC11002793
OpenAlexW4393070934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.