Evidence map›Paper›PMID 38596536›Full record

ArticleMolecular therapy. Methods & clinical development2024

A toxicology study of

Paritha Arumugam, Brenna C Carey, Kathryn A Wikenheiser-Brokamp, Jeffrey Krischer, Matthew Wessendarp, Kenjiro Shima, Claudia Chalk, Jennifer Stock, Yan Ma, Diane Black and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Molecular therapy. Methods & clinical development · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 2 countries.

Paritha ArumugamTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Brenna C CareyTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Kathryn A Wikenheiser-BrokampDivision of Pulmonary Biology, Perinatal Institute, CCHMC, Cincinnati, OH, USA.
Jeffrey KrischerDepartments of Pediatrics and Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL, USA.
Matthew WessendarpTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Kenjiro ShimaTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Claudia ChalkTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Jennifer StockTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Yan MaTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Diane BlackTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Michelle ImbrognoTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Margaret CollinsTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Dan Justin Kalenda YomboDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, UCMC, Cincinnati, OH, USA.
Haripriya SakthivelWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Takuji SuzukiTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Carolyn LutzkoDepartment of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.
Jose A CancelasDivision of Experimental Hematology, CCHMC, Cincinnati, OH, USA.
Michelle AdamsOffice for Clinical and Translational Research, CCHMC, Cincinnati, OH, USA.
Elizabeth HoskinsOffice for Clinical and Translational Research, CCHMC, Cincinnati, OH, USA.
Dawn Lowe-DanielsTranslational Core Laboratory, CCHMC, Cincinnati, OH, USA.
Lilith ReevesTranslational Core Laboratory, CCHMC, Cincinnati, OH, USA.
Anne KaiserOffice of Research Compliance & Regulatory Affairs, CCHMC, Cincinnati, OH, USA.
Bruce C TrapnellTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USCore Laboratories (United States) · USUniversity of Cincinnati · USOncology Hematology Care · USPerinatal Institute · GBProcter & Gamble (United States) · USPurdue University West Lafayette · USUniversity of South Florida · US

Funding

Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Grant Sanford Schulert · 2016 to 2026
$7.7M
Role of GM-CSF in Myeloid Cell Function and Innate ImmunityR01HL085453 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C · 2007 to 2023
$6.5M
Pulmonary Macrophage Transplantation for Pulmonary Alveolar ProteinosisR01HL118342 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C, TRAPNELL, BRUCE COLSTON · 2014 to 2021
$4.5M
Role of GM-CSF in Alveolar Macrophage Self-RenewalR01HL149743 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI ARUMUGAM, PARITHA · 2022 to 2025
$2.1M
Mitochondria mediated intercellular metabolic coupling in bone marrow regenerationR01DK124115 · NIDDK · DANA-FARBER CANCER INST · PI Jose A. Cancelas · 2020 to 2026
$1.9M
Genome edited iPS cell-derived macrophages as a novel lung cell therapyR01HL136721 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SUZUKI, TAKUJI · 2017 to 2020
$1.6M
NHLBI NIH HHS R01 HL085453NHLBI NIH HHS R01 HL118342NHLBI NIH HHS R01 HL136721NHLBI NIH HHS R01 HL149743NIAMS NIH HHS P30 AR070549NIDDK NIH HHS R01 DK124115
6 · The paper itself

Abstract

Pulmonary macrophage transplantation (PMT) is a gene and cell transplantation approach in development as therapy for hereditary pulmonary alveolar proteinosis (hPAP), a surfactant accumulation disorder caused by mutations in

Indexed as

alveolar macrophagebiodistributionCsf2ra complementationhereditary PAPlentiviral vectormacrophage transplantationrepeat ascending dosesingle ascending dosesurfactanttoxicology

Identifiers

PMID38596536
PMCPMC11001781
OpenAlexW4392787028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.