Evidence map›Paper›PMID 38596291›Full record

ArticleMolecular therapy. Oncology2024

A dual-luciferase bioluminescence system for the assessment of cellular therapies.

Alejandro G Torres Chavez, Mary K McKenna, Kishore Balasubramanian, Lisa Riffle, Nimit L Patel, Joseph D Kalen, Brad St Croix, Ann M Leen, Pradip Bajgain

Open access · diamondAbstract read
In one paragraph

Article in Molecular therapy. Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Alejandro G Torres ChavezCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Mary K McKennaCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Kishore BalasubramanianTexas A&M Health Science Center School of Medicine, Bryan, TX 77807, USA.
Lisa RiffleSmall Animal Imaging Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA.
Nimit L PatelSmall Animal Imaging Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA.
Joseph D KalenSmall Animal Imaging Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA.
Brad St CroixTumor Angiogenesis Unit, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Ann M LeenCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Pradip BajgainTumor Angiogenesis Unit, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Baylor College of Medicine · USLeidos (United States) · USNational Cancer Institute · USTexas A&M Health Science Center · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Tissue ResourceP50CA126752 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Leonid S Metelitsa · 2007 to 2026
$51.4M
VECTOR PRODUCTIONP01CA094237 · NCI · BAYLOR COLLEGE OF MEDICINE · PI HESLOP, HELEN E, ROONEY, CLIONA M. · 2002 to 2017
$27.8M
Functional Analysis of TEM5 and TEM8ZIABC010484 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ST CROIX, BRADLEY D · 2009 to 2025
$9.3M
NCI NIH HHS P01 CA094237NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA126752
6 · The paper itself

Abstract

Bioluminescence imaging is a well-established platform for evaluating engineered cell therapies in preclinical studies. However, despite the discovery of new luciferases and substrates, optimal combinations to simultaneously monitor two cell populations remain limited. This makes the functional assessment of cellular therapies cumbersome and expensive, especially in preclinical

Indexed as

Akalucbioluminescence imagingCAR T cellsCBG99cell therapydual-luciferaseMT: Regular Issue

Identifiers

PMID38596291
PMCPMC10869576
OpenAlexW4390990351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.