Evidence map›Paper›PMID 38595635›Full record

ArticleJournal of pharmacy & bioallied sciences2024

CNS Demyelination Syndromes Following COVID-19 Vaccination: A Case Series.

Yasser Hamed, Abd-Elaziz Shokry, Khaled Mohamed Ali Shehata, Salma Mokhtar Osman, Khaled Saad, Safwat Salama Sawy, Emad Abdelrazzak, Omran Mohamed Abdelmola, Tarek Mansour

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of pharmacy & bioallied sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yasser HamedDepartment of Neurology, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt.
Abd-Elaziz ShokryDepartment of Neurology, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt.
Khaled Mohamed Ali ShehataDepartment of Internal Medicine, Faculty of Medicine, Assiut University Hospital, Assiut University, Assiut, Egypt.
Salma Mokhtar OsmanDepartment of Internal Medicine, Faculty of Medicine, Assiut University Hospital, Assiut University, Assiut, Egypt.
Khaled SaadDepartment of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Safwat Salama SawyDepartment of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt.
Emad AbdelrazzakDepartment of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt.
Omran Mohamed AbdelmolaDepartment of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University-Assiut Branch, Egypt.
Tarek MansourDepartment of Radiodiagnosis, Faculty of Medicine, Al-Azhar University- Assiut Branch, Egypt.
Al-Azhar University · EGAssiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Although immunization against coronavirus disease 2019 (COVID-19) is ongoing, adverse reactions to these vaccinations have been observed in isolated cases. We aimed to report different neurological complications developed after COVID-19 vaccination. Materials and Methods: In our case series study, we report all cases of CNS demyelination following COVID-19 immunization. Clinical evaluation, brain MRI, and CSF analysis for oligoclonal bands and IgG index were performed for all patients. Other investigations were performed for selected patients, including spine MRI, EEG, VEP, and aquaporin-4. Results: Eighteen patients (eight males and ten females) with no history of COVID-19 infection had neurological manifestations (vertigo, ataxia, recurrent attacks of loss of consciousness, optic neuritis, and myelitis) starting within 14 days after Pfizer ( Conclusion: This study identified CNS demyelination complications after COVID-19 vaccination. The COVID-19 vaccination could result in CNS complications, possibly connected to a post-vaccination inflammatory process. We recommend continuous post-marketing monitoring for adverse reactions in individuals who received the vaccines to establish a connection and guarantee the long-term safety of COVID-19 vaccines.

Indexed as

COVID-19demyelinationmyelitisvaccines

Identifiers

PMID38595635
PMCPMC11000968
OpenAlexW4392303942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.