Evidence map›Paper›PMID 38595236›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2024

[Developmental toxicity of Cry1Ab protein in the embryonic stem-cell model].

Yuanzhi Jian, Fei Wang, Ning Yin, Ruoyu Zhou, Junbo Wang

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuanzhi JianDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Fei WangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Ning YinDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Ruoyu ZhouDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Junbo WangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the developmental toxicity of Cry1Ab protein by studying its effects on cell proliferation and differentiation ability using a developmental toxicity assessment model based on embryonic stem-cell.

methodsCry1Ab protein was tested in seven dose groups (31.25, 62.50, 125.00, 250.00, 320.00, 1 000.00, and 2 000.00 μg/L) on mouse embryonic stem cells D3 (ES-D3) and 3T3 mouse fibroblast cells, with 5-fluorouracil (5-FU) used as the positive control and phosphate buffer saline (PBS) as the solvent control. Cell viability was detected by CCK-8 assay to calculate the 50% inhibitory concentration (IC

resultsThe IC

conclusionNo developmental toxicity of Cry1Ab protein at concentrations ranging from 31.25 to 2 000.00 μg/L was observed in this experimental model.

Indexed as

Embryonic Stem CellsMyocytes, CardiacAnimalsCell DifferentiationFluorouracilMiceRNA, MessengerSolventsFluorouracilRNA, MessengerSolventsCardiac myocytesCell differentiationCry1Ab proteinDevelopmental toxicityEm-bryonic stem cells

Identifiers

PMID38595236
PMCPMC11004948
OpenAlexW4394763196

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.