Evidence map›Paper›PMID 38595235›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2024

[Expression relationship and significance of NEAT1 and miR-27a-3p in serum and cerebrospinal fluid of patients with Alzheimer disease].

Lijie He, Chunyan Zhang, Jing Wang

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lijie HeDepartment of Laboratory, Tianjin Fifth Central Hospital, Tianjin 300450, China.
Chunyan ZhangTianjin Key Laboratory of Organ Development Epigenetics of Premature Infants, Tianjin Fifth Central Hospital, Tianjin 300450, China.
Jing WangDepartment of Laboratory, Tianjin Fifth Central Hospital, Tianjin 300450, China.
Fifth Tianjin Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the expression relationship and significance of long chain non-coding RNA nuclear-enriched abundant transcript 1 (LncRNA NEAT1) and miR-27a-3p in serum and cerebrospinal fluid of patients with Alzheimer disease (AD).

methodsSixty-six AD patients received by the department of neurology of our hospital from October 2019 to September 2021 were gathered, according to the clinical dementia rating scale score, they were grouped into mild group (≤1 point,

resultsThe MMSE score [21 (17, 25), 9(7, 11)

conclusionThe expression trends of NEAT1 and miR-27a-3p in the serum and cerebrospinal fluid of AD patients are consistent, the level of NEAT1 is increased, and the level of miR-27a-3p is decreased. The levels of the two are negatively correlated, which is related to the degree of Aβ deposition in the brain of AD patients and is involved in the progression of AD.

Indexed as

Alzheimer DiseaseMicroRNAsRNA, Long NoncodingAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesHumansPeptide FragmentsAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesMicroRNAsPeptide FragmentsRNA, Long NoncodingAlzheimer disease(AD)Amyloid β (Aβ)CorrelationLong chain non-coding RNA nuclear-enriched abundant transcript 1 (LncRNA NEAT1)miR-27a-3p

Identifiers

PMID38595235
PMCPMC11004957
OpenAlexW4394757744

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.