Evidence map›Paper›PMID 38594570›Full record

ArticleBiochemical genetics2025

The Expression Analysis of Long Non-coding RNAs Related to Wnt/β-Catenin Signaling in Pancreatic Cancer Patients.

Fatemeh Katoozian, Zahra Abedi Kichi, Roya Sharifi, Zeinab Shirvani-Farsani

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Article in Biochemical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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2 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Fatemeh KatoozianDepartment of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
Zahra Abedi KichiDepartment of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Roya SharifiDepartment of Medical Laboratory Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. sharifi.r@iums.ac.ir.
Zeinab Shirvani-FarsaniDepartment of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran. z_shirvani@sbu.ac.ir.
Shahid Beheshti University · IRIran University of Medical Sciences · IRLudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The oncogenic Wnt/β-catenin signaling plays a critical role in carcinogenesis, prognosis, and resistance to therapy. Pancreatic cancer (PC) has high mortality because of its poor prognosis. Several studies have suggested that lncRNAs are directly involved in the development and progression of PC as well as in Wnt/β-catenin signaling. In this study, we investigated and compared the expression of Wnt/β-catenin signaling-related ZFAS1 and HCG11 lncRNAs, and their targets, CTNNB1 and IGF2BP1 genes in the blood of patients with PC and healthy individuals. A total of 47 PC patients and 50 healthy individuals participated in this study. RNA was extracted from the peripheral blood samples of participants, and cDNA was synthesized. The expression level of the selected genes was quantified by real-time PCR. The expression of HCG11 lncRNA and CTNNB1 genes in patients with PC was significantly upregulated compared to healthy individuals, and the expression of the ZFAS1 lncRNA was significantly downregulated. According to the analysis of the ROC curve, the diagnostic powers of ZFAS1 and CTNNB1 in PC were 0.67 and 0.69, respectively. Altogether, the present study suggests a role for ZFAS1 and HCG11 lncRNAs and CTNNB1 and IGF2BP1 in the pathogenesis of pancreatic cancer. Moreover, the peripheral expression of these lncRNAs may be useful as potential biomarkers for PC.

Indexed as

beta CateninGene Expression Regulation, NeoplasticPancreatic NeoplasmsRNA, Long NoncodingWnt Signaling PathwayAdultAgedBiomarkers, TumorCase-Control StudiesFemaleHumansMaleMiddle AgedRNA-Binding Proteinsbeta CateninBiomarkers, TumorCTNNB1 protein, humanIGF2BP1 protein, humanRNA-Binding ProteinsRNA, Long NoncodingZFAS1 long non-coding RNA, humanBiomarkerHCG11Long non-coding RNAPancreatic cancerZFAS1

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PMID38594570
OpenAlexW4394598531

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.