Evidence map›Paper›PMID 38594558›Full record

ArticleEuropean radiology experimental2024

Hyperpolarized [1-

Gigin Lin, Ching-Yi Hsieh, Ying-Chieh Lai, Chun-Chieh Wang, Yenpo Lin, Kuan-Ying Lu, Wen-Yen Chai, Albert P Chen, Tzu-Chen Yen, Shu-Hang Ng and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European radiology experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04951921 (Precision Medicine Imaging for Cervical Cancer), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04951921 phase2completednot on this map

Precision Medicine Imaging for Cervical Cancer: Integrating MR Fingerprinting, Dynamic Nuclear Polarization (DNP)-MRI and Artificial Intelligence Radiomics

TypeinterventionalSponsorChang Gung Memorial HospitalRan2021 to 2024Enrolled6ConditionsCervical CancerArmsHyperpolarized 13C Pyruvate
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. The Combined Prognostic Value ofCancer medicine · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Gigin LinDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing St, Guishan, 33382, Taoyuan, Taiwan. giginlin@cgmh.org.tw.ORCID http://orcid.org/0000-0001-7246-1058
Ching-Yi HsiehDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing St, Guishan, 33382, Taoyuan, Taiwan.
Ying-Chieh LaiDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing St, Guishan, 33382, Taoyuan, Taiwan.
Chun-Chieh WangDepartment of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.
Yenpo LinDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing St, Guishan, 33382, Taoyuan, Taiwan.
Kuan-Ying LuDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing St, Guishan, 33382, Taoyuan, Taiwan.
Wen-Yen ChaiDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing St, Guishan, 33382, Taoyuan, Taiwan.
Albert P ChenGE Healthcare, Toronto, Canada.
Tzu-Chen YenDepartment of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Shu-Hang NgDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing St, Guishan, 33382, Taoyuan, Taiwan.
Chyong-Huey LaiDivision of Gynecologic Oncology, Gynecologic Oncology Research Center, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.
Chang Gung University · TWChang Gung Memorial Hospital · TWChang Gung University of Science and Technology · TWGeneral Electric (Canada) · CA

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

backgroundMonitoring pyruvate metabolism in the spleen is important for assessing immune activity and achieving successful radiotherapy for cervical cancer due to the significance of the abscopal effect. We aimed to explore the feasibility of utilizing hyperpolarized (HP) [1-

methodsThis prospective study recruited six female patients with cervical cancer (median age 55 years; range 39-60) evaluated using HP [1-

resultsThe splenic HP [1-

conclusionsThis exploratory study revealed the feasibility of HP [1-

trial registrationClinicalTrials.gov NCT04951921 , registered 7 July 2021. RELEVANCE STATEMENT: This prospective study revealed the feasibility of using HP KEY POINTS: • Effective radiotherapy induces abscopal effect via altering immune metabolism. • Hyperpolarized

Indexed as

Pyruvic AcidUterine Cervical NeoplasmsCarbon-13 Magnetic Resonance SpectroscopyFemaleHumansLactatesMiddle AgedProspective StudiesLactatesPyruvic AcidCarbon-13Magnetic resonance spectroscopyRadiotherapySpleenUterine cervical neoplasms

Identifiers

PMID38594558
PMCPMC11003947
OpenAlexW4394761084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.