ReviewInternational ophthalmology2024
Higher order aberrations in keratoconus.
Review in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 6 citations in OpenAlex.
- Comparative analysis of higher-order aberration profiles in macular and granular corneal dystrophies.International ophthalmology · 2026Article
- Visual performance of a non-diffractive extended depth of focus IOL in stable early-stage Keratoconus: prospective pilot study.International ophthalmology · 2026Article
- Outcomes of keraring implantation for high regular astigmatism in non-ectatic corneas: A prospective pilot case series.Scientific reports · 2026Article
- Corneal Higher-Order Aberrations and Posterior Segment Changes in Keratoconus: A Multimodal OCT and OCTA Study.Diagnostics (Basel, Switzerland) · 2026Article
- Deep-stromal implantation of a double-crosslinked bioengineered porcine collagen implant (BPCDX) in advanced keratoconus: a 12-month study of corneal remodeling and visual outcomes.Scientific reports · 2026Article
- Long-term outcomes of lamellar crescentic wedge resection on corneal astigmatism and optical aberrations in patients with advanced pellucid marginal degeneration.Turkish journal of medical sciences · 2026Article
- Management of astigmatism in keratoconus with therapeutic refractive surgery.Frontiers in medicine · 2026Review
- Normative Data of Higher-Order Aberrations in Healthy Caucasian Eyes and Their Correlation with Age, Gender, and Spherical Equivalent.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Effects of customized corneal cross-linking on higher-order aberrations in progressive keratoconus and low-grade myopia.Acta ophthalmologica · 2025Article
- Comparison of visual quality after monocular and binocular trifocal intraocular lens implantation during cataract surgery: a prospective study.BMC ophthalmology · 2025Observational
- Relationship between objective and subjective refraction measurements in patients with mild keratoconus.International journal of ophthalmology · 2025Article
- Characteristics of corneal aberration in patients with bilateral keratoconus and unilateral corneal Vogt's striae.International journal of ophthalmology · 2024Article
- The impact of contact lenses on binocular vision in patients with Keratoconus.Journal of optometryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionKeratoconus is a progressive disorder of the cornea that causes thinning (Sedaghat et al. in Sci Rep 11(1):11971, 2021), ectasia, and irregular astigmatism, resulting in poor visual acuity that cannot be corrected with standard sphero-cylindrical spectacle lenses. One feature distinguishing keratoconic corneas is ocular aberrations, manifesting up to five or six times the amount of higher-order aberrations than a normal, healthy eye. These aberrations can cause visual disturbances even at the very early stages of the disease.
methodsIn the past, a diagnosis was derived from clinical symptoms, but technological advances have revealed multiple pre-clinical features, allowing for the differentiation between keratoconic and normal eyes at a much earlier stage. These include anterior and posterior corneal surface elevations, the corneal pachymetry profile, corneal epithelial patterns, wavefront aberration metrics, and corneal biomechanics (Sedaghat et al. in Sci Rep 11(1):11971, 2021).This review discusses the aberrations associated with keratoconus, how to measure them, and treatment methods to minimize their negative influence.
conclusionsEarly diagnosis can lead to early treatment and may allow for arresting progression, thereby improving the long-term prognosis. With the acceleration of refractive surgery, it is important to identify patients with keratoconus, as they are usually contraindicated for refractive surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.