Evidence map›Paper›PMID 38594485›Full record

ArticleArchives of virology2024

Genetic and virological characteristics of a reassortant avian influenza A H6N1 virus isolated from wild birds at a live-bird market in Egypt.

Omnia Kutkat, Mokhtar Gomaa, Basma Emad Aboulhoda, Yassmin Moatasim, Ahmed El Taweel, Mina Nabil Kamel, Mohamed El Sayes, Amany Elkhrsawy, Hend AbdAllah, Ahmed Kandeil and 5 more

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Article in Archives of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Omnia KutkatCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.
Mokhtar GomaaCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.
Basma Emad AboulhodaDepartment of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt.
Yassmin MoatasimCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.
Ahmed El TaweelCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.
Mina Nabil KamelCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.
Mohamed El SayesCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.
Amany ElkhrsawyCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.
Hend AbdAllahDepartment of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt.
Ahmed KandeilCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.
Pamela P McKenzieDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Richard J WebbyDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Mohamed Ahmed AliCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.
Ghazi KayaliHuman Link, Dubai, United Arab Emirates. ghazi@human-link.org.ORCID http://orcid.org/0000-0002-5387-1622
Rabeh El-SheshenyCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt. rabeh.elshesheny@human-link.org.
National Research Centre · EGSt. Jude Children's Research Hospital · USCairo University · EGLink Institut (Switzerland) · CH

Funding

Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases 5N93021C00016
6 · The paper itself

Abstract

The first detection of a human infection with avian influenza A/H6N1 virus in Taiwan in 2013 has raised concerns about this virus. During our routine surveillance of avian influenza viruses (AIVs) in live-bird markets in Egypt, an H6N1 virus was isolated from a garganey duck and was characterized. Phylogenetic analysis indicated that the Egyptian H6N1 strain A/Garganey/Egypt/20869C/2022(H6N1) has a unique genomic constellation, with gene segments inherited from different subtypes (H5N1, H3N8, H7N3, H6N1, and H10N1) that have been detected previously in AIVs from Egypt and some Eurasian countries. We examined the replication of kinetics of this virus in different mammalian cell lines (A549, MDCK, and Vero cells) and compared its pathogenicity to that of the ancestral H6N1 virus A/Quail/HK/421/2002(H6N1). The Egyptian H6N1 virus replicated efficiently in C57BL/6 mice without prior adaptation and grew faster and reached higher titers than in A549 cells than the ancestral strain. These results show that reassortant H6 AIVs might pose a potential threat to human health and highlight the need to continue surveillance of H6 AIVs circulating in nature.

Indexed as

Influenza A virusInfluenza A Virus, H3N8 SubtypeInfluenza A Virus, H5N1 SubtypeInfluenza in BirdsAnimalsAnimals, WildChlorocebus aethiopsDucksEgyptHumansInfluenza A Virus, H7N3 SubtypeMammalsMiceMice, Inbred C57BLPhylogenyVero Cells

Identifiers

PMID38594485
OpenAlexW4394598510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.