ArticleDigestive diseases and sciences2024
Serum Lactate Is an Indicator for Short-Term and Long-Term Mortality in Patients with Acute Pancreatitis.
Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 13 citations in OpenAlex.
- Risk analysis of the association between lactate-to-hematocrit ratio and poor prognosis in critical patients with cirrhosis.Medicine · 2026Article
- Post-translational modification crosstalk in acute pancreatitis: linking acinar stress to innate immune amplification and tissue repair.Frontiers in immunology · 2026Review
- Early prognostic value of the lactate-to-albumin ratio in severe acute pancreatitis with acute respiratory distress syndrome.Frontiers in medicine · 2026Article
- Clinical utility of the lactate-to-albumin ratio for predicting mortality in elderly severe acute pancreatitis.Frontiers in medicine · 2026Article
- Lactate and H3K18 Lactylation Contribute To the Exacerbation of Acute Pancreatitis by Modulating NCOA4-mediated Ferroptosis.Inflammation · 2025Article
- Observational
- Associations of lactate-to-hematocrit ratio with short- and long-term prognoses in critically ill patients with cirrhosis and sepsis: a retrospective cohort study.BMC infectious diseases · 2025Article
- Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis.BMC gastroenterology · 2025Article
- Non-linear association between lactate and 28 days mortality in elderly patients with sepsis across different SOFA score groups: results from the eICU Collaborative Research Database.Frontiers in medicine · 2025Article
- Article
- Relationship between preoperative high arterial blood lactate level and delirium after deep brain stimulation surgery in Parkinson's disease.Frontiers in aging · 2025Article
- Association between lactate/albumin ratio and prognosis in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy.Renal failure · 2024Article
- Interpretable machine learning for early prediction of acute kidney injury in critically ill patients with acute pancreatitis.Digital healthArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSerum lactate, as a single and an easily available biomarker, has been applied in various diseases.
aimsIn this study, we aimed to explore the predictive value of serum lactate for short-term and long-term prognosis in acute pancreatitis (AP) admitted in intensive care unit (ICU) based on a large-scale database.
methodsAP patients admitted in ICU in the MIMIC-IV database were included. We constructed three different models to investigate the relationships between serum lactate and clinical outcomes, including 30-day, 180-day and 1-year mortality in AP. Smooth fitting curves were performed for intuitively demonstrating the relationship between serum lactate and different outcomes in AP by the generalized additive model.
resultsA total of 895 AP patients admitted in ICU were included. The mortalities of 30 days, 180 days, and 1 year were 12.63% (n = 113), 16.87% (n = 151), and 17.54% (n = 157). In model B, with 1-mmol/L increment in serum lactate, the values of OR in 30-day, 180-day and 1-year mortality were 1.20 (95%CI 1.04-1.37, P = 0.0094), 1.21 (95%CI 1.06-1.37, P = 0.0039), and 1.21 (95%CI 1.07-1.38, P = 0.0035). The AUCs of serum lactate for predicting 30-day, 180-day, and 1-year mortality in AP were 0.688 (95%CI 0.633-0.743), 0.655 (95%CI 0.605-0.705), and 0.653 (95%CI 0.603-0.701), respectively. The cut-off value of serum lactate predicting 30-day, 180-day and 1-year mortality in AP was 2.4 mmol/L.
conclusionSerum lactate could be an indicator for short-term and long-term mortality in patients with AP admitted in ICU.
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