Evidence map›Paper›PMID 38594425›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Earlier age of symptom onset in younger generation of familial cases of multiple sclerosis.

Aleksa Jovanovic, Tatjana Pekmezovic, Sarlota Mesaros, Ivana Novakovic, Borut Peterlin, Nikola Veselinovic, Olivera Tamas, Jovana Ivanovic, Gorica Maric, Marko Andabaka and 2 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aleksa JovanovicInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Tatjana PekmezovicInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Sarlota MesarosClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Ivana NovakovicInstitute of Medical Genetics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Borut PeterlinClinical Institute for Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Nikola VeselinovicClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Olivera TamasClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Jovana IvanovicClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Gorica MaricInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Marko AndabakaClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Nikola MomcilovicClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Jelena DrulovicClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia. drulovicjelena@gmail.com.ORCID http://orcid.org/0000-0002-4516-3458

Funding

Wellcome Trust 200110
6 · The paper itself

Abstract

aimThe aim of this study was to assess the prevalence of familial MS (fMS) in Belgrade MS population, discern the differences between the persons with fMS and sporadic MS, and to detect the presence of anticipation phenomenon in fMS patients.

methodsThe data on the demographic and clinical characteristics of MS patients was obtained from the Belgrade MS population Registry. In cases of vertical transmission of MS, the family members were divided into the younger and older generation, in order to assess the potential presence of anticipation phenomenon. To adjust for follow-up time bias, a secondary analysis including only patients who had the onset of symptoms before 39 years (75.percentile), and those who were 39 + years, was performed.

resultsThe prevalence of fMS in Belgrade MS population is 6.4%. FMS cases had earlier age at MS symptom onset (30.4 vs. 32.3 years) compared to sporadic MS cohort. When comparing fMS cases across generations, the younger generation had significantly lower age at onset compared with the older one (25.8 vs. 35.7 years, p < 0.001). After adjustment for the different length of the follow-up, the difference in age at symptom onset between the groups was reduced, but it still existed and was statistically significant (30.0 years in younger vs. 36.4 years in older generation, p = 0.040).

conclusionIn our study, the analysis of fMS cases across generations, showed an earlier age of symptom onset in the younger generation, even after adjustment. These results indicate the possibility of existence of anticipation phenomenon.

Indexed as

Age of OnsetMultiple SclerosisAdultAnticipation, GeneticFemaleHumansMaleMiddle AgedPrevalenceRegistriesSerbiaYoung AdultAnticipationFamilial multiple sclerosisFamilial occurrencePrevalence

Identifiers

PMID38594425

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.