Evidence map›Paper›PMID 38594414›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2025

High vs low CPAP strategy with aerosolized calfactant in preterm infants with respiratory distress syndrome.

D C Kaluarachchi, E Gerday, T Bahr, H A Zapata, M R Lasarev, S O Guthrie, S Minton

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

D C KaluarachchiDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA. kaluarachchi@pediatrics.wisc.edu.ORCID 0000-0001-8334-6282
E GerdayUtah Valley Hospital, Provo, UT and Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
T BahrUtah Valley Hospital, Provo, UT and Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-7946-0290
H A ZapataDepartment of Pediatrics, Division of Neonatology, University of Florida School of Medicine -Jacksonville, Jacksonville, FL, USA.
M R LasarevDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-1896-2705
S O GuthrieDepartment of Pediatrics, Division of Neonatology, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0001-9703-5266
S MintonUtah Valley Hospital, Provo, UT and Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
University of Utah · USUniversity of Wisconsin–Madison · USUniversity of Florida · USVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOptimal CPAP strategy to prevent CPAP failure defined as need for endotracheal intubation is unknown.

objectiveTo evaluate the risk of CPAP failure in infants treated with high vs low CPAP strategy while receiving aerosolized calfactant in the AERO-02 clinical trial and AERO-03 expanded access program.

methodsInfants born between 29 0/7 to 36 6/7 weeks were included. Comparisons were made between low and high CPAP groups (Low, 4-7 cm H

resultsCPAP failure and pneumothorax were not different between the groups. Odds of CPAP failure were not different after adjustment for baseline characteristics (OR = 0.61; 95% CI: 0.29, 1.24).

conclusionWe found no difference in CPAP failure among infants who received aerosolized calfactant that were treated with high vs low CPAP strategy. Efficacy of high CPAP strategy with aerosolized surfactant treatment needs to be evaluated in future studies.

Indexed as

Biological ProductsContinuous Positive Airway PressureInfant, PrematurePulmonary SurfactantsRespiratory Distress Syndrome, NewbornAdministration, InhalationAerosolsFemaleGestational AgeHumansInfant, NewbornIntubation, IntratrachealMalePneumothoraxTreatment FailureAerosolsBiological ProductscalfactantPulmonary Surfactants

Identifiers

PMID38594414
OpenAlexW4394596543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.