ArticleBritish journal of cancer2024
Trajectory patterns and cumulative burden of CEA during follow-up with non-small cell lung cancer outcomes: A retrospective longitudinal cohort study.
Article in British journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Diagnostic performance of multimodal biomarkers in colorectal cancer.Scientific reports · 2026Observational
- Upfront Surgery for c-Stage IIIB Non-Small Cell Lung Cancer with an Abnormally High Preoperative Serum Carcinoembryonic Antigen Level: A Case Report.Surgical case reports · 2026Article
- Non-Destructively Quantifying the Whole-Course Growth and Drug-Response of PDOs by an Automatic Microfluidic System Utilizing Chemiluminescence Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The heterogeneous expression patterns of serum tumor markers in non-small cell lung cancer patients are predictive factors for progression-free survival.Discover oncology · 2025Article
- Value of serum LncRNA KIF9-AS1 combined with CT signs in the diagnosis of benign and malignant early pulmonary nodules and its correlation with prognosis.Journal of cardiothoracic surgery · 2025Article
- Carcinoembryonic Antigen (CEA): Origin, Role in Oncology, and Concentrations in Serum and Peritoneal Fluid.Journal of clinical medicine · 2025Review
- A prognostic nutritional index-based nomogram for predicting postoperative survival in stages I-III rectal cancer patients.Frontiers in nutrition · 2025Article
- Association between CONUT scores and survival outcomes in patients with non-small cell lung cancer: meta-analysis from 4973 Asian cases.Frontiers in oncology · 2025Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies of non-small cell lung cancer (NSCLC) focused on CEA measured at a single time point, ignoring serial CEA measurements.
methodsThis retrospective cohort included 2959 patients underwent surgery for stage I-III NSCLC. CEA trajectory patterns and long-term cumulative CEA burden were evaluated using the latent class growth mixture model.
resultsFour CEA trajectory groups were identified, named as low-stable, decreasing, early-rising and later-rising. Compared with the low-stable group, the adjusted hazard ratios associated with death were 1.27, 4.50, and 3.68 for the other groups. Cumulative CEA burden were positively associated with the risk of death in patients not belonging to the low-stable group. The 5-year overall survival (OS) rates decreased from 62.3% to 33.0% for the first and fourth quantile groups of cumulative CEA burden. Jointly, patients with decreasing CEA trajectory could be further divided into the decreasing & low and decreasing & high group, with 5-year OS rates to be 77.9% and 47.1%. Patients with rising CEA trajectory and high cumulative CEA were found to be more likely to develop bone metastasis.
conclusionsLongitudinal trajectory patterns and long-term cumulative burden of CEA were independent prognostic factors of NSCLC. We recommend CEA in postoperative surveillance of NSCLC.
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