Evidence map›Paper›PMID 38594350›Full record

ArticleCommunications medicine2024

Dynamic SARS-CoV-2 surveillance model combining seroprevalence and wastewater concentrations for post-vaccine disease burden estimates.

Rochelle H Holm, Grzegorz A Rempala, Boseung Choi, J Michael Brick, Alok R Amraotkar, Rachel J Keith, Eric C Rouchka, Julia H Chariker, Kenneth E Palmer, Ted Smith and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rochelle H Holm *Christina Lee Brown Envirome Institute, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.ORCID http://orcid.org/0000-0001-8849-1390
Grzegorz A Rempala *Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA.ORCID http://orcid.org/0000-0002-6307-4555
Boseung Choi *Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA.
J Michael BrickWestat, Inc., Rockville, MD, 20850, USA.ORCID http://orcid.org/0000-0003-3490-8925
Alok R AmraotkarChristina Lee Brown Envirome Institute, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.
Rachel J KeithChristina Lee Brown Envirome Institute, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.
Eric C RouchkaDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.ORCID http://orcid.org/0000-0003-3487-6572
Julia H CharikerDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.
Kenneth E PalmerCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, 40202, USA.ORCID http://orcid.org/0000-0002-2811-1111
Ted SmithChristina Lee Brown Envirome Institute, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.ORCID http://orcid.org/0000-0003-2804-4294
Aruni BhatnagarChristina Lee Brown Envirome Institute, School of Medicine, University of Louisville, Louisville, KY, 40202, USA. aruni.bhatnagar@louisville.edu.

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI J CHRISTOPHER STATES · 2020 to 2026
$10.0M
NIEHS NIH HHS P30 ES030283NIGMS NIH HHS P20 GM103436
6 · The paper itself

Abstract

backgroundDespite wide scale assessments, it remains unclear how large-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination affected the wastewater concentration of the virus or the overall disease burden as measured by hospitalization rates.

methodsWe used weekly SARS-CoV-2 wastewater concentration with a stratified random sampling of seroprevalence, and linked vaccination and hospitalization data, from April 2021-August 2021 in Jefferson County, Kentucky (USA). Our susceptible (

resultsHere we show the 64% county vaccination rate translate into about a 61% decrease in SARS-CoV-2 incidence. The estimated effect of SARS-CoV-2 Delta variant emergence is a 24-fold increase of infection counts, which correspond to an over 9-fold increase in wastewater concentration. Hospitalization burden and wastewater concentration have the strongest correlation (r = 0.95) at 1 week lag.

conclusionsOur study underscores the importance of continuing environmental surveillance post-vaccine and provides a proof-of-concept for environmental epidemiology monitoring of infectious disease for future pandemic preparedness.

Identifiers

PMID38594350
PMCPMC11004132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.