Evidence map›Paper›PMID 38594294›Full record

ArticleScientific reports2024

Parafoveal cone function in choroideremia assessed with adaptive optics optoretinography.

Peiluo Xu, Robert F Cooper, Yu You Jiang, Jessica I W Morgan

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. ƒ(Cell): Software for Reproducible Analysis of Optoretinograms.Translational vision science & technology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Retinal Sensitivity in Comparison to Cone Density in Choroideremia.Investigative ophthalmology & visual science · 2024
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Peiluo XuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Robert F CooperDepartment of Ophthalmology, Joint Department of Biomedical Engineering, Medical College of Wisconsin, Marquette University and Medical College of Wisconsin, Milwaukee, WI, 53233, USA.
Yu You JiangScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jessica I W MorganScheie Eye Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. jwmorgan@pennmedicine.upenn.edu.
University of Pennsylvania · USMedical College of Wisconsin · USPenn Presbyterian Medical Center · US

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Retinal structure, function and response to gene therapyR01EY028601 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Jessica I.W. Morgan · 2018 to 2026
$3.6M
Imaging Photoreceptor FunctionR01EY030227 · NEI · UNIVERSITY OF PENNSYLVANIA · PI David H. Brainard, Jessica I.W. Morgan · 2020 to 2026
$1.8M
Foundation Fighting Blindness BR-CL-0619-0768-UPANEI NIH HHS P30 EY001583NEI NIH HHS R01 EY028601NEI NIH HHS R01 EY030227NIH HHS NIH R01EY028601, NIH R01EY030227, NIH P30EY001583
6 · The paper itself

Abstract

Choroideremia (CHM) is an X-linked retinal degeneration leading to loss of the photoreceptors, retinal pigment epithelium (RPE), and choroid. Adaptive optics optoretinography is an emerging technique for noninvasive, objective assessment of photoreceptor function. Here, we investigate parafoveal cone function in CHM using adaptive optics optoretinography and compare with cone structure and clinical assessments of vision. Parafoveal cone mosaics of 10 CHM and four normal-sighted participants were imaged with an adaptive optics scanning light ophthalmoscope. While acquiring video sequences, a 2 s 550Δ10 nm, 450 nW/deg

Indexed as

ChoroideremiaChoroidHumansOphthalmoscopyRetinal Cone Photoreceptor CellsRetinal Pigment EpitheliumTomography, Optical Coherence

Identifiers

PMID38594294
PMCPMC11004114
OpenAlexW4394598758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.