Evidence map›Paper›PMID 38594193›Full record

ArticleBMJ paediatrics open2024

Association of cerebral palsy with autism spectrum disorder and attention-deficit/hyperactivity disorder in children: a large-scale nationwide population-based study.

Qiang Chen, Mingwu Chen, Wei Bao, Lane Strathearn, Xiaodong Zang, Lun Meng, Guifeng Xu

Open access · diamondAbstract read
In one paragraph

Article in BMJ paediatrics open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Qiang ChenZhuhai Women and Children's Hospital, Zhuhai, China.
Mingwu ChenDepartment of Pediatrics, University of Science and Technology of China, Hefei, Anhui, China.
Wei BaoUniversity of Science and Technology of China, Hefei, Anhui, China.
Lane StrathearnUniversity of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
Xiaodong ZangDepartment of Pediatrics, University of Science and Technology of China, Hefei, Anhui, China.
Lun MengDepartment of Pediatrics, University of Science and Technology of China, Hefei, Anhui, China.
Guifeng XuDepartment of Pediatrics, University of Science and Technology of China, Hefei, Anhui, China xguifeng365@ustc.edu.cn.ORCID http://orcid.org/0000-0001-9031-9960
University of Science and Technology of China · CNUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the association of cerebral palsy with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), providing evidence for interdisciplinary medical service for children with cerebral palsy.

designA large-scale nationwide population-based study.

settingThe National Health Interview Survey (NHIS). PATIENTS: 177 899 children aged 3-17 years among NHIS participants from 1997 to 2003 and 2008 to 2018.

resultsAmong the 177 899 children included in this analysis, 602 (0.33%) had cerebral palsy, 1997 (1.16%) had ASD, and 13 697 (7.91%) had ADHD. Compared with children without cerebral palsy, children with cerebral palsy had a higher prevalence of ASD (6.09% vs 1.15%; p<0.001) and ADHD (15.91% vs 7.89%; p<0.001). After adjustment for age, sex, race/ethnicity, family highest education level, family income level and geographical region, the OR among children with cerebral palsy, compared with children without cerebral palsy, was 5.07 (95% CI 3.25 to 7.91) for ASD (p<0.001) and 1.95 (95% CI 1.43 to 2.66) for ADHD (p<0.001). Furthermore, the association of cerebral palsy with ASD and ADHD remained significant in all subgroups stratified by age, sex and race.

conclusionIn a large, nationally representative sample of US children, this study shows that children with cerebral palsy are at an increased risk of ASD and ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderCerebral PalsyChildHumansPrevalenceSurveys and QuestionnairesEpidemiology

Identifiers

PMID38594193
PMCPMC11015243
OpenAlexW4394766305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.