ArticleThe journal of nutrition, health & aging2024
Reproductive factors and risk of physical frailty among Chinese women living in Singapore.
Article in The journal of nutrition, health & aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Life satisfaction mediates advanced maternal age at childbirth and frailty across cohorts.iScience · 2026Article
- Associations between reproductive factors and frailty in middle-aged and older women: evidence from the China health and retirement longitudinal study.Journal of health, population, and nutrition · 2025Article
- Applying a life course approach to elucidate the biology of sex differences in frailty: early-life gonadectomy diminishes late-life robustness in male and female dogs in the Exceptional Aging in Rottweilers Study.Biology of sex differences · 2025Article
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Authors and funding
5 authors.
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Abstract
settingAlthough age at menopause has been linked to higher risk of physical frailty in later life, little is known about other reproductive factors.
objectivesOur study aimed to investigate the associations between 1) age at menarche, 2) age at natural menopause, 3) duration of reproductive period, 4) number of children, 5) use of oral contraceptives (OCP), and 6) use of hormone replacement therapy (HRT) with the risk of physical frailty in late life.
designWe used data from 5934 women of the Singapore Chinese Health Study who experienced natural menopause, and participated in the third follow-up interviews when physical frailty was assessed. Logistic regression was used to evaluate association of reproductive factors evaluated during baseline and prior follow-up interviews with physical frailty at follow-up 3.
participantsCommunity-dwelling Chinese women living in Singapore. Participants had a mean age of 52.6 years at baseline (1993-1998), and a mean age of 72.8 years during the third follow-up (2014-2017). MEASUREMENTS: Sociodemographic characteristics, level of education, smoking history, physical activity, and history of physician-diagnosed comorbidities were collected. Participants' weight and height were self-reported. We used a modified Cardiovascular Health Study phenotype to assess physical frailty.
resultsAge at menarche was inversely associated with the likelihood of physical frailty (P
conclusionsIn our population-based cohort of Chinese women, younger ages at menarche and menopause were associated with higher likelihood of physical frailty in later life.
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