Evidence map›Paper›PMID 38593368›Full record

ArticleSmall methods2024

Facile Peptide Macrocyclization and Multifunctionalization via Cyclen Installation.

Tsz-Lam Cheung, Leo K B Tam, Wing-Sze Tam, Leilei Zhang, Hei-Yui Kai, Waygen Thor, Yue Wu, Pak-Lun Lam, Yik-Hoi Yeung, Chen Xie and 4 more

Abstract read
In one paragraph

Article in Small methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tsz-Lam CheungDepartment of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Kowloon, Hong Kong, China.ORCID 0000-0002-4303-1494
Leo K B TamDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0002-2436-0057
Wing-Sze TamDepartment of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Kowloon, Hong Kong, China.ORCID 0000-0002-9288-0804
Leilei ZhangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, and College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
Hei-Yui KaiDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0001-9960-7467
Waygen ThorDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0002-4366-9113
Yue WuDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0001-7296-8182
Pak-Lun LamDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0002-3558-7855
Yik-Hoi YeungDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0001-8446-4694
Chen XieDepartment of Clinical Oncology, University of Hong Kong, Pok Fu Lam, Hong Kong Island, Hong Kong, China.ORCID 0000-0003-0998-3245
Ho-Fai ChauDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0001-6964-1840
Wai-Sum LoDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0001-5329-4581
Tao ZhangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, and College of Biophotonics, South China Normal University, Guangzhou, 510631, China.ORCID 0000-0001-6855-0162
Ka-Leung WongDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0002-3750-5980

Funding

Centre for Medical Engineering of Molecular and Biological Probes AoE/M-401/20Hong Kong Research Grants Council, University Grants Committee 12300021NSFC/RGC Joint Research Scheme N_PolyU209/21
6 · The paper itself

Abstract

Cyclen-peptide bioconjugates are usually prepared in multiple steps that require individual preparation and purification of the cyclic peptide and hydrophilic cyclen derivatives. An efficient strategy is discovered for peptide cyclization and functionalization toward lanthanide probe via three components intermolecular crosslinking on solid-phase peptide synthesis with high conversion yield. Multifunctionality can be conferred by introducing different modular parts or/and metal ions on the cyclen-embedded cyclopeptide. As a proof-of-concept, a luminescent Eu

Indexed as

CyclamsMagnetic Resonance ImagingPeptides, CyclicAnimalsContrast MediaCyclizationEuropiumGadoliniumHumansMiceOligopeptidesOptical ImagingSolid-Phase Synthesis Techniquesarginyl-glycyl-aspartic acidContrast MediaCyclamscyclenEuropiumGadoliniumOligopeptidesPeptides, Cycliccyclen‐peptide conjugateslanthanidesluminescencesolid phase peptide synthesisαvβ3 integrin

Identifiers

PMID38593368
PMCPMC11579550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.