Evidence map›Paper›PMID 38593277›Full record

ArticleEpilepsia open2024

COVID-19 response in a long-term care facility for people with epilepsy.

Luisa Delazer, Noah Pressler, Simona Balestrini, Fenglai Xiao, Lisa M Clayton, Jonny Anders-Cannon, Rebecca Salvatierra, Ian Henry, Sanjay M Sisodiya, Josemir W Sander and 1 more

Open access · goldAbstract read
In one paragraph

Article in Epilepsia open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 5 countries.

Luisa DelazerChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.ORCID https://orcid.org/0009-0002-1330-3628
Noah PresslerUniversity of Nottingham, Medical School, Nottingham, UK.
Simona BalestriniChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.ORCID https://orcid.org/0000-0001-5639-1969
Fenglai XiaoChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.ORCID https://orcid.org/0000-0003-1308-6539
Lisa M ClaytonChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.ORCID https://orcid.org/0000-0002-1928-8054
Jonny Anders-CannonChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.
Rebecca SalvatierraChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.
Ian HenryChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.
Sanjay M SisodiyaChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.ORCID https://orcid.org/0000-0002-1511-5893
Josemir W SanderChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.ORCID https://orcid.org/0000-0001-6041-9661
Matthias J KoeppChalfont Centre for Epilepsy, Chalfont St Peter, Bucks, UK.ORCID https://orcid.org/0000-0002-4277-8000
National Hospital for Neurology and Neurosurgery · GBEpilepsy Society · GBSichuan University · CNMeyer Children's Hospital · ITUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess asymptomatic rates and severity of SARS-CoV-2 infection in people with epilepsy and their healthcare workers in a long-term care facility which had implemented weekly surveillance testing between April 2020 and June 2022.

methodsQuestionnaires focused on objective and subjective COVID-19 symptoms for people with epilepsy residing in and their healthcare workers at the Chalfont Centre for Epilepsy in June 2022. Demographic information, comorbidities, and seizure frequency were gathered from medical records. We also collected responses on objective and subjective COVID-19 symptoms from healthcare workers who participated in a prospective study assessing the reaction to COVID-19 vaccinations (SAFER).

resultsFifty-five out of 89 (62%) residents tested positive at least once on weekly PCR testing for SARS-CoV-2 during the period of interest; 20 of those (37%) were asymptomatic. In comparison, of those 63 healthcare workers who tested positive at least once on weekly testing during the same period, only four (6%) were asymptomatic. Of the 159 healthcare workers who also participated in the SAFER study, 41 tested positive at least once, and seven (17%) were completely asymptomatic during infection with SARS-CoV-2. SIGNIFICANCE: People with epilepsy living in a long-term care facility were more likely to present with asymptomatic SARS-CoV-2 infections than healthcare workers at the same facility. Despite possible bias in the reporting of subjective symptoms due to management-by-proxy, there is no evidence that vulnerable people living in an epilepsy long-term care facility showed reduced resilience towards infections. PLAIN LANGUAGE SUMMARY: People with epilepsy living in care home facilities had a surprisingly high degree of asymptomatic infections with SARS-CoV-2. Very few residents had severe or fatal outcomes. This is in stark contrast to the widely reported bad outcomes for people without epilepsy in other care homes. People with epilepsy reported significantly less symptoms than their healthcare workers. No changes in seizure frequency during or after infection were observed.

Indexed as

COVID-19EpilepsyHealth PersonnelLong-Term CareAdultAgedAsymptomatic InfectionsCOVID-19 VaccinesFemaleHumansMaleMiddle AgedProspective StudiesSARS-CoV-2Surveys and QuestionnairesCOVID-19 Vaccinesasymptomatic ratefatality ratioSARS‐CoV‐2seizures

Identifiers

PMID38593277
PMCPMC11145605
OpenAlexW4394622580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.