Evidence map›Paper›PMID 38593228›Full record

ArticleCancer discovery2024

St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors.

Gavriel Y Matt, Edgar Sioson, Kyla Shelton, Jian Wang, Congyu Lu, Airen Zaldivar Peraza, Karishma Gangwani, Robin Paul, Colleen Reilly, Aleksandar Acić and 17 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Cancer discovery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Characterization of Genetic Etiologic Factors for Pediatric Acute Lymphoblastic Leukemia in Large Childhood Cancer Survivorship Cohorts.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. NCI-Funded Cancer Epidemiology Survivor Cohorts: Overview, Progress, and Opportunities.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  9. Review
  10. Article
  11. ppHiC: Interactive exploration of Hi-C results on the ProteinPaint web portal.Computational and structural biotechnology journal · 2024
    Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 3 institutions in 2 countries.

Gavriel Y Matt *Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-6200-8487
Edgar Sioson *Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-7540-8516
Kyla Shelton *Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-0135-0745
Jian Wang *Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-1902-1528
Congyu LuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-2651-6251
Airen Zaldivar PerazaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0009-0008-3234-2925
Karishma GangwaniDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-2986-4481
Robin PaulDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-3727-8025
Colleen ReillyDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-3119-9940
Aleksandar AcićDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0009-0006-6113-9999
Qi LiuSchool of Public Health, University of Alberta, Edmonton, Canada.ORCID 0000-0002-7208-515X
Stephanie R SandorDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0009-0003-4997-8499
Clay McLeodDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-6437-8334
Jaimin PatelDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-6754-6030
Fan WangDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-9806-5037
Cindy ImDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota.ORCID 0000-0003-0931-9432
Zhaoming WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-7556-3869
Yadav SapkotaDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-5943-9454
Carmen L WilsonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-7636-065X
Nickhill BhaktaDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-5282-7833
Kirsten K NessDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-2084-1507
Gregory T ArmstrongDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-8722-4207
Melissa M HudsonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-6984-2407
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-7460-8578
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-3350-9682
Yutaka YasuiDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-7717-8638
Xin ZhouDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-3979-8200
St. Jude Children's Research Hospital · USUniversity of Alberta · CAUniversity of Minnesota Medical Center · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
The St. Jude Lifetime CohortU01CA195547 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HUDSON, MELISSA M, NESS, KIRSTEN KIMBERLIE · 2015 to 2024
$14.9M
Predicting and Preventing Chemotherapy-InducedCardiotoxicity in African American ChildrenR01CA261898 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BURRIDGE, PAUL W., SAPKOTA, YADAV · 2021 to 2025
$3.6M
Late Effects Prediction using Clinical Phenotypes and Whole Genome SequencingR01CA216354 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YASUI, YUTAKA, ZHANG, JINGHUI · 2017 to 2021
$3.4M
Measuring Lifelong Multimorbidity with Patient Perspectives: Implementing and Visualizing the Cumulative Burden Methodology Across CohortsR01CA270157 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BHAKTA, NICKHILL HITESH, YASUI, YUTAKA · 2022 to 2025
$1.8M
American Lebanese Syrian Associated Charities (ALSAC)National Institutes of Health (NIH) CA195547National Institutes of Health (NIH) CA216354National Institutes of Health (NIH) CA261898National Institutes of Health (NIH) CA270157National Institutes of Health (NIH) CA55727NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA216354NCI NIH HHS R01 CA261898NCI NIH HHS R01 CA270157NCI NIH HHS U01 CA195547NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

Childhood cancer survivorship studies generate comprehensive datasets comprising demographic, diagnosis, treatment, outcome, and genomic data from survivors. To broadly share this data, we created the St. Jude Survivorship Portal (https://survivorship.stjude.cloud), the first data portal for sharing, analyzing, and visualizing pediatric cancer survivorship data. More than 1,600 phenotypic variables and 400 million genetic variants from more than 7,700 childhood cancer survivors can be explored on this free, open-access portal. Summary statistics of variables are computed on-the-fly and visualized through interactive and customizable charts. Survivor cohorts can be customized and/or divided into groups for comparative analysis. Users can also seamlessly perform cumulative incidence and regression analyses on the stored survivorship data. Using the portal, we explored the ototoxic effects of platinum-based chemotherapy, uncovered a novel association between mental health, age, and limb amputation, and discovered a novel haplotype in MAGI3 strongly associated with cardiomyopathy specifically in survivors of African ancestry. Significance: The St. Jude Survivorship Portal is the first data portal designed to share and explore clinical and genetic data from childhood cancer survivors. The portal provides both open- and controlled-access features and will fulfill a wide range of data sharing needs of the survivorship research community and beyond. See co-corresponding author Xin Zhou discuss this research article, published simultaneously at the AACR Annual Meeting 2024: https://vimeo.com/932617204/7d99fa4958.

Indexed as

Cancer SurvivorsGenomicsNeoplasmsAdolescentChildFemaleHumansInformation DisseminationMaleSurvivorship

Identifiers

PMID38593228
PMCPMC11294819
OpenAlexW4394622651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.