Evidence map›Paper›PMID 38593156›Full record

ArticleScience signaling2024

Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection.

Wenjiao Wu, Vinothini Arunagiri, Hanh Chi Do-Umehara, Cong Chen, Shuyin Gu, Indrani Biswas, Karen M Ridge, G R Scott Budinger, Shuwen Liu, Jing Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Wenjiao WuDepartment of Surgery, College of Medicine, Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.
Vinothini ArunagiriDepartment of Surgery, College of Medicine, Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-2824-7609
Hanh Chi Do-UmeharaDepartment of Surgery, College of Medicine, Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-3368-1602
Cong ChenDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Shuyin GuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Indrani BiswasDepartment of Surgery, College of Medicine, Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.
Karen M RidgeDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-3114-5208
Shuwen LiuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.ORCID 0000-0001-6346-5006
Jing LiuDepartment of Surgery, College of Medicine, Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-4699-1375
University of Illinois Chicago · USNorthwestern University · USSouthern Medical University · CN

Funding

The transcription factor Miz1-mediated mechanisms of lung agingR01HL141459 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIU, JING · 2018 to 2021
$2.0M
NHLBI NIH HHS R01 HL141459
6 · The paper itself

Abstract

Type I interferons (IFNs) are critical for the antiviral immune response, and fine-tuning type I IFN production is critical to effectively clearing viruses without causing harmful immunopathology. We showed that the transcription factor Miz1 epigenetically repressed the expression of genes encoding type I IFNs in mouse lung epithelial cells by recruiting histone deacetylase 1 (HDAC1) to the promoters of

Indexed as

Influenza A virusInfluenza, HumanInterferon Type IAnimalsEpithelial CellsGene Expression RegulationHumansInterferonsMiceProtein Inhibitors of Activated STATUbiquitinationUbiquitin-Protein LigasesVirus ReplicationInterferonsInterferon Type IMiz1 protein, mouseProtein Inhibitors of Activated STATUbiquitin-Protein Ligases

Identifiers

PMID38593156
PMCPMC11182629
OpenAlexW4394596779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.